{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:14Z","timestamp":1747185434487,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003354","name":"Garnett Passe and Rodney Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vestibular migraine (VM) is a common cause of recurrent vertigo. Migraine headache preventative therapies are currently prescribed to control vertigo symptoms in VM. Clinical trials of nutraceuticals for migraine headache prevention have shown positive outcomes, but, to date, there have been no studies to assess their effectiveness in the management of VM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To report the effects of nonprescription therapy management on VM symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a prospective, questionnaire\u2010based assessment of patients diagnosed with VM between November 2019 and August 2021 at two Sydney tertiary referral clinics. Patients were advised on optimising sleep, hydration, exercise and nutrition and instructed to use an over\u2010the\u2010counter combination product containing riboflavin 200 mg, magnesium 150 mg, coenzyme Q10 75 mg and feverfew 200 mcg. Symptom severity and frequency were assessed using the Dizziness Handicap Inventory (DHI), the Vertigo Symptom Score short\u2010form (VSS\u2010sf) and two visual analogue scales for severity (VAS\u2010s) and frequency (VAS\u2010f) before and 3 months after commencing treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In 82 participants (78% female;\u00a0mean age, 44 \u00b1\u200914\u2009years) we recorded a decrease in DHI (mean, 16.8 [95% confidence interval (CI), 12.8\u201320.9], VSS\u2010sf (9.3, 7.1\u201311.5), VAS\u2010s (3.0, 2.2\u20133.8) and VAS\u2010f (2.8, 2.1\u20133.4), equating to an improvement of 44.1%, 44.9%, 44.1% and 38.9% for each measure respectively. On the DHI and VSS\u2010sf, 41 (50%) and 44 (53.7%) patients showed improvement in their symptoms; 39 (47.6%) and 36 (43.9%) patients noted no change and two patients reported worsening. The supplement was well\u2010tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results provide preliminary evidence that VM symptom frequency and severity can be reduced by using nonprescription therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16314","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:34:25Z","timestamp":1704958465000},"page":"916-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of nonprescription therapies on vestibular migraine: a questionnaire\u2010based observational study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7204-9514","authenticated-orcid":false,"given":"Imelda P.","family":"Hannigan","sequence":"first","affiliation":[{"name":"Central Clinical School University of Sydney  Sydney New South Wales Australia"},{"name":"Blacktown Neurology Clinic  Blacktown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally M.","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Central Clinical School University of Sydney  Sydney New South Wales Australia"},{"name":"Institute of Clinical Neurosciences, Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian L.","family":"Di Tanna","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Science Division The\u00a0George Institute for Global Health, Faculty of Medicine, University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun R. 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