{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:05:10Z","timestamp":1776924310981,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Sleep\u2010disordered breathing (SDB) and nocturnal hypoxemia were known to be present in patients with chronic thromboembolic pulmonary hypertension (CTEPH), but the difference between\u00a0SDB and nocturnal hypoxemia in patients who have chronic thromboembolic pulmonary disease (CTEPD) with or without pulmonary hypertension (PH) at rest remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had CTEPH (<jats:italic>n<\/jats:italic> =\u200980) or CTEPD without PH (<jats:italic>n<\/jats:italic>\u00a0=\u200940) and who had undergone sleep studies from July 2020 to October 2022 at Shanghai Pulmonary Hospital were enrolled. Nocturnal mean SpO<jats:sub>2<\/jats:sub> (Mean SpO<jats:sub>2<\/jats:sub>) &lt;90% was defined as nocturnal hypoxemia, and the percentage of time with a saturation below 90% (T90%) exceeding 10% was used to evaluate the severity of nocturnal hypoxemia. Logistic and linear regression analyses were performed to investigate the difference and potential predictor of SDB or nocturnal hypoxemia between CTEPH and CTEPD without PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SDB was similarly prevalent in CTEPH and CTEPD without PH (<jats:italic>P<\/jats:italic> =\u20090.104), both characterised by obstructive sleep apnoea (OSA). Twenty\u2010two patients with CTEPH were diagnosed with nocturnal hypoxemia, whereas only three were diagnosed with CTEPD without PH (<jats:italic>P<\/jats:italic> =\u20090.021). T90% was positively associated with mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance in patients with CTEPH and CTEPD without PH (<jats:italic>P<\/jats:italic> &lt;\u20090.001); T90% was also negatively related to cardiac output in these patients. Single\u2010breath carbon monoxide diffusing capacity, sex and mPAP were all correlated with nocturnal hypoxemia in CTEPH and CTEPD without PH (all <jats:italic>P<\/jats:italic> &lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nocturnal hypoxemia was worse in CTEPD with PH; T90%, but not SDB, was independently correlated with the hemodynamics in CTEPD with or without PH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16359","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:21:25Z","timestamp":1712071285000},"page":"1292-1301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sleep\u2010disordered breathing and nocturnal hypoxemia in chronic thromboembolic pulmonary disease"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-6338","authenticated-orcid":false,"given":"Hui\u2010Ting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the 416 Hospital of Nuclear Industry\/the Second Affiliated Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Gang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ci\u2010Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-9982","authenticated-orcid":false,"given":"Jin\u2010Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.09.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.12.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3528"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1378"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.02.112"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019885364"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341182"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0636"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515602"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4458-20"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.12.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.33"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.971077"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.09.118"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2019.04.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02258-2020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01779-x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02964-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.6.473"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1910"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.3.685"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0112-2016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13141"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07556-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0899-2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.027"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:41:24Z","timestamp":1724028084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/imj.16359"],"URL":"https:\/\/doi.org\/10.1111\/imj.16359","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}