{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:23Z","timestamp":1747185443842,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Highly effective hepatitis C therapies are available in Australia. However, people living with hepatitis C face various barriers to accessing care and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify gaps in the cascade of care for hepatitis C and generate estimates of the number living with untreated infection according to population group, using a representative longitudinal study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We linked hepatitis C notification data from Victoria to national pathology, prescribing and death registry data. We assessed receipt of key clinical services in a large cohort who tested positive for hepatitis C from 1 January 2000 to 31 December 2016, with follow\u2010up to 30 June 2018. We estimated the number still living with hepatitis C, adjusting for spontaneous clearance and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised 45\u2009391 people positive for hepatitis C. Of these, 13\u2009346 (29%) received treatment and an estimated 28% (95% confidence interval (CI): 26\u201330%) were still living with chronic infection at 30 June 2018, with the remainder still living following spontaneous clearance (30%, 95% CI: 29\u201332%) or having died (12%, 95% CI: 12\u201312%). Half (50%) of those still living with hepatitis C were born from 1965 to 1980, and 74% first tested positive before 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite an enabling policy environment and subsidised therapy, many people in this cohort were not treated. Increased measures may be needed to engage people in care, including those who acquired hepatitis C more than 10\u2009years ago.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16361","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:12:52Z","timestamp":1710911572000},"page":"1146-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The cascade of care for hepatitis C in Victoria, Australia: a data linkage cohort study"],"prefix":"10.1111","volume":"54","author":[{"given":"Kathryn","family":"Snow","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Viral Hepatitis The Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-4536","authenticated-orcid":false,"given":"Jennifer H.","family":"MacLachlan","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Viral Hepatitis The Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Rowe","sequence":"additional","affiliation":[{"name":"Victorian Government Department of Health  Melbourne Victoria Australia"},{"name":"School of Population Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasra","family":"Higgins","sequence":"additional","affiliation":[{"name":"Victorian Government Department of Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.","family":"Cowie","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Viral Hepatitis The Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases University of Melbourne  Melbourne Victoria Australia"},{"name":"Victorian Infectious Diseases Service Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"volume-title":"Schedule of Pharmaceutical Benefits Summary of Changes March 2016","year":"2016","author":"Australian Government Department of Health","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12852"},{"key":"e_1_2_7_4_1","unstructured":"The Kirby Institute. 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The First Year of COVID\u201019 in Australia: Direct and Indirect Health Effects; 2021."},{"volume-title":"Viral Hepatitis Mapping Project: Geographic Diversity in Chronic Hepatitis B and C Prevalence, Management and Treatment","year":"2021","author":"MacLachlan J","key":"e_1_2_7_6_1"},{"volume-title":"Global Progress Report on HIV, Viral Hepatitis and Sexually Transmitted Infections, 2021","year":"2021","author":"World Health Organization","key":"e_1_2_7_7_1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14324"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13453"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12560"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2017.07.006"},{"key":"e_1_2_7_12_1","unstructured":"The Kirby Institute. Monitoring Hepatitis C Treatment Uptake in Australia: Issue 12. 2021 July 2022. 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