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Although typically slow\u2010growing and responsive to frontline therapies, advanced\u2010stage FL remains incurable with current treatments and typically follows a chronic relapsing\/remitting course with increasingly shorter responses to subsequent lines of therapy. Outcomes are highly variable; some patients experience prolonged first remissions that may approximate a \u2018functional cure\u2019. By contrast, a significant minority of patients experience disease progression shortly after frontline treatment resulting in high rates of lymphoma\u2010related mortality. Reflecting on the heterogeneous natural history of FL, clinical practice varies widely, particularly in controversial areas, including appropriate disease staging, selection of management strategies and duration of clinical follow\u2010up. 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