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Few patients do not progress to kidney failure in their lifetime even in population groups previously thought to be low risk. The previously established treatment approach predominantly focuses on supportive care through renin\u2013angiotensin\u2013aldosterone system inhibition and steroid\u2010based immunosuppression in selected cases. However, recent advances in the understanding of the pathogenic mechanisms underlying this disease process have allowed for the development of new target therapies. This brief review provides an overview of improved understanding of IgA nephropathy and novel therapeutic strategies.<\/jats:p>","DOI":"10.1111\/imj.16539","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T14:57:44Z","timestamp":1728572264000},"page":"1779-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunoglobulin A nephropathy is not what it used to be!"],"prefix":"10.1111","volume":"54","author":[{"given":"Shriram","family":"Swaminathan","sequence":"first","affiliation":[{"name":"Nephrology and Transplantation Unit John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-5512","authenticated-orcid":false,"given":"Bobby","family":"Chacko","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Unit John Hunter Hospital  Newcastle New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509997"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg207"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.02.246"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011050464"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.14340"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0600"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204233"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02074-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.01.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01554-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.01.031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305635"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.05.017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.12.014"},{"key":"#cr-split#-e_1_2_8_19_1.1","unstructured":"Omeros Corporation.Study of the safety and efficacy of OMS721 in patients with immunoglobulin A (IgA) nephropathy (ARTEMIS\u2010IGAN). Identifier NCT03608033[updated 2024 Mar 15"},{"key":"#cr-split#-e_1_2_8_19_1.2","unstructured":"cited 2024 Aug 5]. Available from URL:http:\/\/clinicaltrials.gov\/"},{"key":"e_1_2_8_20_1","unstructured":"PerkovicV KollinsD RenfurmR et al.Efficacy and safety of iptacopan in patients with IgA nephropathy: interim results from the phase 3 APPLAUSE\u2010IgAN study. 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