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These factors are particularly prominent in Central Australia. Inadequate housing has led to some of the highest rates of <jats:italic>Streptococcus pyogenes<\/jats:italic> infection in the world, which in turn drives an extremely high prevalence of rheumatic heart disease. Food insecurity and inadequate social protection manifesting as energy insecurity result in inadequate nutrition and have resulted in a huge burden of diabetes in Central Australia. These factors, combined with social exclusion, racism and the pervasive effect of colonisation, also drive a high rate of alcohol misuse. Only by prioritising equity in these \u2018social determinants\u2019 and emphasising the importance of First Nations leadership in formulating and implementing solutions will health inequity be addressed.<\/jats:p>","DOI":"10.1111\/imj.16548","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T11:40:42Z","timestamp":1729942842000},"page":"2077-2082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The heart of the matter: a re\u2010iteration of the role of the social determinants of health in addressing health inequity in <scp>Central Australia<\/scp>"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2580-3110","authenticated-orcid":false,"given":"William","family":"Naughton","sequence":"first","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-7012","authenticated-orcid":false,"given":"Angus A.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"},{"name":"School of Medicine, Flinders University Rural Clinical School  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"},{"name":"School of Medicine, Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Holwell","sequence":"additional","affiliation":[{"name":"Department of Medicine Alice Springs Hospital  Alice Springs Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"Social Determinants of Health","author":"Australian Institute of Health and Welfare","year":"2024"},{"key":"e_1_2_2_3_1","volume-title":"Key Policies for Addressing the Social Determinants of Health and Health Inequities","author":"Saunders M","year":"2017"},{"key":"e_1_2_2_4_1","unstructured":"M. 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