{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:25Z","timestamp":1787014345265,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The frequency of EoE has been increasing in Northern Hemisphere cohorts, yet there is a scarcity of data in our region. Regional climatic factors, and lifestyle habits may influence the presentation of EoE, and appropriate management is crucial to prevent complications. WIth this is mind we undertook the first comprehensive multisite study of EoE in Australasian children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the incidence, prevalence, clinical characteristics and management of eosinophilic esophagitis (EoE) in Australasian children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective audit of endoscopic records, histology reports and case notes (ICD code) over a 10\u2010year period (1 January 2008 to 31 December 2018). Cases were defined as having &gt;15 eosinophils per high\u2010power field (HPF) at endoscopy and oesophageal biopsy, while treatment response was defined as &lt;5 eosinophils per HPF. Included were patients aged 0\u201318 years presenting to tertiary paediatric hospitals in seven capital cities (Adelaide, Auckland, Brisbane, Christchurch, Melbourne, Perth and Sydney), while those with conditions that could cause eosinophilia (organ transplantation, hyper\u2010eosinophilic syndrome) or taking medications that may influence tissue eosinophilia (systemic corticosteroids immunosuppressants) were excluded. Australian Bureau of Statistics and Stats NZ were used to define comparative population data. Demographics (age at diagnosis, gender, country of birth, race) comorbidities (atopic conditions, e.g. asthma, seasonal rhinitis, eczema) and treatment (diet, steroids, proton pump inhibitors) were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of EoE ranged from 15 to 54 per 100\u2009000 children, where cases were more common in Adelaide than other localities. Incidence increased significantly in all sites across the 10\u2009years, with peak incidence in Adelaide of 6.4 per 100\u2009000 children in 2017. EoE was most frequent in males (male:female ratio\u2009=\u20093:1) and &gt;90% were white Caucasian. Polynesian racial background in Auckland (10%) and middle eastern racial background in Sydney (10%) were the next most frequent. Treatment choice varied across sites, and greater than 30% of patients did not undergo endoscopy to assess initial treatment success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of EoE in Australasian children is comparable to that observed elsewhere, and the incidence is increasing significantly. Regional differences in disease frequency, management practices and access to endoscopy warrant further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.16558","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T11:33:42Z","timestamp":1735040022000},"page":"284-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and management of eosinophilic esophagitis in Australasian children: a decade of experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Hamish","family":"Philpott","sequence":"first","affiliation":[{"name":"Department of Gastroenterology North Adelaide Local Health Network  Adelaide South Australia Australia"},{"name":"University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Lemberg","sequence":"additional","affiliation":[{"name":"Paediatrics Department University of NSW, Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Day","sequence":"additional","affiliation":[{"name":"Paediatric Department University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harveen","family":"Singh","sequence":"additional","affiliation":[{"name":"Paediatrics Department University of NSW, Sydney Children's Hospital  Sydney New South Wales Australia"},{"name":"Department of Gastroenterology Monash Childrens Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rumore","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Queensland Children's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ellison","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Couper","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Porter","sequence":"additional","affiliation":[{"name":"Paediatric Department University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Roberts","sequence":"additional","affiliation":[{"name":"Gastroenterology\/Hepatology Service Starship Children's Hospital  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Thacker","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Gastroenterology Department Westmead Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moore","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Furata","sequence":"additional","affiliation":[{"name":"Digestive Health (Gastroenterology and Hepatology) Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-8275","authenticated-orcid":false,"given":"Ajay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Joondalup Health Campus  Perth Western Australia Australia"},{"name":"SJOG Midland Hospital and Curtin Medical School  Perth Western Australia Australia"},{"name":"Perth Paediatrics  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb139022.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.100974"},{"key":"e_1_2_6_7_1","unstructured":"Australian Bureau of Statistics. National State and Territory Population. ABS. 2020 Jun. Available from URL:https:\/\/www.abs.gov.au\/statistics\/people\/population\/national-state-and-territory-population\/jun-2020"},{"key":"e_1_2_6_8_1","unstructured":"Stats NZ. National Population Estimates. 2020 Mar 31. Available from URL:https:\/\/www.stats.govt.nz.information"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.018"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.044"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.06.058"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T01:01:52Z","timestamp":1744506112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/imj.16558"],"URL":"https:\/\/doi.org\/10.1111\/imj.16558","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]},"assertion":[{"value":"2024-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}