{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T14:05:10Z","timestamp":1750255510404,"version":"3.40.3"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is associated with various cardiovascular abnormalities, including spontaneous coronary artery dissection and atrial fibrillation. However, limited data exist to describe the association between ADPKD and acute coronary syndrome or heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This systematic review and meta\u2010analysis evaluated the occurrence of cardiovascular events among patients with ADPKD compared to those without ADPKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted using Embase, PubMed and Scopus databases. Of 416 initially identified articles, 18 of them were reviewed in detail, and three cohort studies, comprising a total of 7888 patients with ADPKD, were included in the final analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with patients without ADPKD, the pooled data revealed that ADPKD patients had a significantly higher odds of any adverse cardiovascular events (odds ratio (OR) 1.36; 95% confidence interval (CI): 1.24\u20131.28), including myocardial infarction (OR 1.86; 95% CI: 1.05\u20133.32) and congestive heart failure (OR 1.36; 95% CI: 1.22\u20131.51). However, there was no significant difference in mortality (OR 1.37; 95% CI: 0.77\u20132.44).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with ADPKD are at a significantly increased risk for major adverse cardiovascular events, such as myocardial infarction and congestive heart failure. Despite the elevated risk of these cardiovascular complications, no significant difference in overall mortality was observed. Further studies are needed to assess ADPKD's cardiovascular risk and possible preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16659","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:30:47Z","timestamp":1741728647000},"page":"493-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute coronary syndrome in patients with autosomal dominant polycystic kidney disease: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-2559","authenticated-orcid":false,"given":"Ashraf","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayssaa","family":"Hoteit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniyal","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salem","family":"Elshenawy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Stolear","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Kaddoura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hamad Medical Corporation  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Buller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"StatPearls.Autosomal Dominant Polycystic Kidney Disease. NCBI Bookshelf[cited 2014 Nov 12]. Available from URL:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532934\/"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.11.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V5122048"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343281"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010183231602"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448296"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529119"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402111309010002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002623"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2054358118774537"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14269"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15050903"},{"volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2024","author":"Higgins JPT","key":"e_1_2_7_16_1"},{"key":"e_1_2_7_17_1","unstructured":"R Studio Team.RStudio: Integrated Development for R. Available from URL:http:\/\/www.rstudio.com\/"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080882"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02330607"},{"key":"e_1_2_7_20_1","first-page":"414","article-title":"Spontaneous coronary artery dissection: one more extrarenal manifestation of autosomal dominant polycystic kidney disease?","volume":"22","author":"Basile C","year":"2009","journal-title":"J Nephrol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.12.007"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.13"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1555-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.05.014"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.07.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.09.020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07217-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.01.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002166"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T02:56:49Z","timestamp":1743562609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/imj.16659"],"URL":"https:\/\/doi.org\/10.1111\/imj.16659","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}