{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:21:27Z","timestamp":1756992087689},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":21410,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1959,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Defects of the aortic wall involving one or more elements were present in five of seven cases of dissecting aneurysm of the aorta occurring in association with Marfan's syndrome ; in two of them no histological abnormality was seen. No significant difference was found in the hexosamine content of the walls (determined in five cases) as compared with that of normal aortas from subjects of the same age group.<\/jats:p><jats:p>Although gross malformation of the aortic wall was present in a minority of cases, both in this series and in previously recorded cases, the basic defect common to all examples of Marfan's syndrome appears to involve the mucopolysaccharides of the intercellular substance. The chemical findings suggest that the defect may be in the degree of polymerization of these polysaccharides, rather than in alteration of the total amount present.<\/jats:p>","DOI":"10.1111\/imj.1959.8.1.45","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T14:35:12Z","timestamp":1505399712000},"page":"45-54","source":"Crossref","is-referenced-by-count":8,"title":["MARFAN'S SYNDROME: THE NATURE OF THE AORTIC DEFECT"],"prefix":"10.1111","volume":"8","author":[{"given":"J. V.","family":"HURLEY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(53)90090-8"},{"key":"e_1_2_1_3_1","first-page":"205","article-title":"Marfan's Syndrome with Unusual Blood Vessel Manifestations","volume":"64","author":"AUSTIN M. G.","year":"1957","journal-title":"A.M.A. Arch. Path."},{"key":"e_1_2_1_4_1","first-page":"309","article-title":"Congenital Aneurysmal Dilatation of the Aorta Associated with Arachnodactyly","volume":"72","author":"BAER R. W.","year":"1943","journal-title":"Bull. Johns Hopk. Hosp."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5019.629"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.02-0467"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02222690"},{"key":"e_1_2_1_8_1","first-page":"257","article-title":"Acid Mucopolysaccharides of the Aorta","volume":"55","author":"BUNTING C. H.","year":"1953","journal-title":"A.M.A. Arch. Path."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.20.1.143"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.8.4.313"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195701032560102"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02158989"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02275142"},{"key":"e_1_2_1_14_1","first-page":"69","article-title":"Three Cases of Marfan's Syndrome","volume":"7","author":"GLASS R.","year":"1957","journal-title":"Alfred Hosp. clin. Rep. (Melbourne)"},{"key":"e_1_2_1_15_1","first-page":"142","article-title":"Pathogenesis of Dissecting Aneurysm of the Aorta","volume":"53","author":"GORE I.","year":"1952","journal-title":"A.M.A. Arch. Path."},{"key":"e_1_2_1_16_1","first-page":"121","article-title":"Dissecting Aneurysm of the Aorta\u2014Pathologic Aspects. An Analysis of Eighty-five Fatal Cases","volume":"53","author":"GORE I.","year":"1952","journal-title":"A.M.A. Arch. Path."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.7.3.373"},{"key":"e_1_2_1_18_1","first-page":"131","article-title":"A Microchemical Reaction Resulting in the Staining of Polysaccharide Structures in Fixed Tissue Preparations","volume":"16","author":"HOTCHKISS R. D.","year":"1948","journal-title":"Arch. Biochem."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1956.5.1.5"},{"key":"e_1_2_1_20_1","first-page":"179","volume-title":"Histopathologic Technique","author":"LILLIE R. D.","year":"1948"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.11.3.321"},{"key":"e_1_2_1_22_1","first-page":"143","article-title":"The Cardiovascular Lesions in Marfan's Syndrome","volume":"61","author":"MACLEOD M.","year":"1956","journal-title":"A.M.A. Arch. Path."},{"key":"e_1_2_1_23_1","first-page":"346","volume":"243","author":"MALLORY T. B.","year":"1950","journal-title":"Mass. gen. Hosp. Case Rec."},{"key":"e_1_2_1_24_1","first-page":"220","article-title":"Un cas de d\u00e9formation cong\u00e9nitale des quatres membres, plus prononc\u00e9e aux extr\u00e9mit\u00e9s, caract\u00e9ris\u00e9e par l'allongement des os avec un certain degr\u00e9 d'amincissement","volume":"13","author":"MARFAN A. B.","year":"1896","journal-title":"Bull. Soc. m\u00e9d. h\u00f4p. Paris"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90054-3"},{"key":"e_1_2_1_26_1","unstructured":"Massachusetts General Hospital Case Records (1957) 256 30."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700730126"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4723.81"},{"key":"e_1_2_1_29_1","first-page":"925","article-title":"Dissecting Aneurysm of the Aorta Associated with Marfan's Syndrome","volume":"1","author":"NEILSEN G. H.","year":"1956","journal-title":"Med. J. Aust."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90322-4"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1926.04130060073003"},{"key":"e_1_2_1_32_1","first-page":"178","article-title":"The Heart in Arachnodactyly","volume":"99","author":"REYNOLDS G.","year":"1950","journal-title":"Guy's Hosp. Rep."},{"key":"e_1_2_1_33_1","first-page":"540","article-title":"Ueber einen Fall von angeborener abnormer Gr\u00f6sse der Extremit\u00e4ten mit einen an Akromegalie erinner den Symptomenkomplex","volume":"75","author":"SALLE V.","year":"1912","journal-title":"Jb. Kinderheilk."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.6.4.299"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90267-2"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1947.00220160054005"},{"key":"e_1_2_1_37_1","first-page":"156","article-title":"Arachnodactyly Associated with Aneurysm of the Aorta","volume":"87","author":"TRAISMAN H. S.","year":"1954","journal-title":"A.M.A. Amer. J. Dis. Child."},{"key":"e_1_2_1_38_1","first-page":"383","article-title":"Marfan's Syndrome\u2014Observations at Necropsy: with Special Reference to Medionecrosis of the Great Vessels","volume":"1","author":"TUNG H. L.","year":"1952","journal-title":"Lab. Invest."},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(54)92505-2"}],"container-title":["Australasian Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.1959.8.1.45","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.1959.8.1.45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:30:32Z","timestamp":1696966232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.1959.8.1.45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1959,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1959,2]]}},"alternative-id":["10.1111\/imj.1959.8.1.45"],"URL":"https:\/\/doi.org\/10.1111\/imj.1959.8.1.45","archive":["Portico"],"relation":{},"ISSN":["0571-9283"],"issn-type":[{"value":"0571-9283","type":"print"}],"subject":[],"published":{"date-parts":[[1959,2]]}}}