{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:22:00Z","timestamp":1697001720897},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":20771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1960,11]]},"abstract":"<jats:p>SUMMARY<\/jats:p><jats:p>Thirteen cases of severe chronic atrophic gastritis were studied over a period ranging from five to 12 years. Diagnosis was established by a history of flatulent dyspepsia, depleted acid secretion and serial gastric biopsies using the suction biopsy tube. There was no evidence of peptic ulcer or cancer.<\/jats:p><jats:p>During the last three years of the study serial assays were made of the serum vitamin B<jats:sub>12<\/jats:sub> levels in these cases. In the majority there was a fall in the level. Also, the mean level was lower than that in a control group in which normal acid secretion was found on histamine stimulation. Absorption studies were made with <jats:sup>58<\/jats:sup>Co labelled vitamin B<jats:sub>12<\/jats:sub>.<\/jats:p><jats:p>These studies indicated the following three clinical states : (i) <jats:italic>pre\u2010pernicious an\u00e6nia,<\/jats:italic> with serum vitamin B<jats:sub>12<\/jats:sub> levels between 100 and 250 \u03bc\u03bcg. per millilitre and normoblastic bone marrow, but no symptoms or perhaps minimal weakness ; (ii) <jats:italic>latent pernicious an\u00e6mia,<\/jats:italic> with a serum vitamin B<jats:sub>12<\/jats:sub> level less than 100 \u03bc\u03bcg. per millilitre, but still a normoblastic bone marrow, and either no symptoms or, at the most, minimal weakness ; (iii) <jats:italic>overt pernicious an\u00e6mia,<\/jats:italic> with a serum vitamin B<jats:sub>12<\/jats:sub> level of less than 100 per millilitre and the classical clinical and bone\u2010marrow changes of pernicious anemia and\/or subacute combined degeneration of the spinal cord.<\/jats:p><jats:p>The findings after a histamine test meal and on gastric biopsy and particularly the serum vitamin B<jats:sub>12<\/jats:sub> level are of considerable value to the physician who suspects prepernicious an\u00e6mia, latent pernicious an\u00e6mia or the early manifestations of overt pernicious an\u00e6mia or subacute combined degeneration of the cord. He may thus save the patient from the severe forms of the disease.<\/jats:p>","DOI":"10.1111\/imj.1960.9.4.309","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T14:05:17Z","timestamp":1505397917000},"page":"309-317","source":"Crossref","is-referenced-by-count":5,"title":["SERUM VITAMIN B<sub>12<\/sub> LEVELS IN CHRONIC ATROPHIC GASTRITIS"],"prefix":"10.1111","volume":"9","author":[{"given":"I. J.","family":"WOOD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"COWLING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"UNGAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"GRAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1959.tb129295.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1950.tb81340.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195903192601202"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(56)90752-8"},{"key":"e_1_2_1_6_1","first-page":"214","article-title":"Studies of Excretion (and Absorption) of Co60-Labelled Vitamin B12 in Pernicious An\u00e6mia","volume":"65","author":"HEINLE R. 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