{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:30:39Z","timestamp":1761766239446},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":20498,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1961,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A review has been made of certain clinical features of 20 episodes of acute h\u00e6molytic anaemia sustained by 15 Australian children of Mediterranean racial extraction. When possible, metabolic studies were made on the erythrocytes of these 15 children.<\/jats:p><jats:p>Deficiency of the enzyme glucose\u20106\u2010phosphate dehydrogenase (G6PD) was found in the erythrocytes of the 13 children tested. Marked instability of reduced glutathione (GSH) and susceptibility to Heinz\u2010body formation on incubation with acetyl phenylhydrazine were demonstrated in the G6PD\u2010deficient erythrocytes of 10 of these 13 children.<\/jats:p><jats:p>The outstanding feature of the clinical study was the high incidence of males, of springtime illness, and of exposure to <jats:italic>Vicia fava<\/jats:italic>. Ingestion of broad beans closely preceded the onset of nine h\u00e6molytic episodes, and five additional episodes occurred in ambulant males in spring. The erythrocytes of these children were characterized by very marked degrees of G6PD deficiency, GSH instability and susceptibility to Heinz\u2010body formation.<\/jats:p><jats:p>A second striking feature was the demonstration of erythrocyte G6PD deficiency in three infants with severe neonatal hyperbilirubin\u00e6mia. One infant had received 2 mg. of a vitamin K analogue, another may have ingested phenacetin or acetylsalicylic acid in maternal breast milk, and in the third case no toxic agent was found. One infant subsequently sustained an attack of favism.<\/jats:p><jats:p>Erythrocyte G6PD deficiency was also found in one child who developed acute h\u00e6molytic an\u00e6mia with acute glomerulonephritis, and in another who sustained a mild h\u00e6molytic episode in association with intestinal salmonellosis.<\/jats:p><jats:p>The relationship between neonatal jaundice, favism and drug\u2010induced h\u00e6molysis has been discussed in terms of the mode of genetic transmission of G6PD deficiency, with reference to the protection of potentially susceptible individuals from potentially h\u00e6molytic agents.<\/jats:p>","DOI":"10.1111\/imj.1961.10.3.192","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:12:35Z","timestamp":1505373155000},"page":"192-200","source":"Crossref","is-referenced-by-count":5,"title":["ACUTE H\u00c6MOLYTIC AN\u00c6MIA IN MEDITERRANEAN CHILDREN WITH GLUCOSE\u20106\u2010PHOSPHATE DEHYDROGENASE\u2014DEFICIENT ERYTHROCYTES"],"prefix":"10.1111","volume":"10","author":[{"given":"JOHN D.","family":"HARLEY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-49-2-240"},{"key":"e_1_2_1_3_1","unstructured":"\u201cAUSTRALIAN IMMIGRATION QUARTERLY STATISTICAL BULLETIN\u201d (1960) No.36(October)."},{"key":"e_1_2_1_4_1","first-page":"40","article-title":"The Hemolytic Effect of Primaquine. VI. An In Vitro Test for Sensitivity of Erythrocytes to Primaquine","volume":"45","author":"BEUTLER E.","year":"1955","journal-title":"J. Lab. clin. Med."},{"key":"e_1_2_1_5_1","first-page":"84","article-title":"The Glutathione Instability of Drug-Sensitive Red Cells. A New Method for the In Vitro Detection of Drug Sensitivity","volume":"49","author":"BEUTLER E.","year":"1957","journal-title":"J. Lab clin. Med."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/189555a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1958.tb58543.x"},{"key":"e_1_2_1_8_1","first-page":"837","volume":"44","author":"BRUNETTI P.","year":"1959","journal-title":"H\u0153matologica"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3220.484-a"},{"key":"e_1_2_1_10_1","first-page":"21","article-title":"A Genetic Study of a Defect in Glutathione Metabolism of the Erythrocytes","volume":"102","author":"CHILDS B.","year":"1958","journal-title":"Bull. Johns Hopk. Hosp."},{"key":"e_1_2_1_11_1","first-page":"91","article-title":"Newsletter\u2014Favism in Sardinia","volume":"11","author":"CROSBY W. H.","year":"1956","journal-title":"Blood"},{"key":"e_1_2_1_12_1","first-page":"43","article-title":"Some Rare Types of Macrocytic Anaemia","volume":"7","author":"DAVIDSON L. S. P.","year":"1938","journal-title":"Quart. J. Med., N.S."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)91476-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/170624a0"},{"key":"e_1_2_1_15_1","volume-title":"Hereditary Enzymatic Defect in Red Blood Cells. Its Relation to Certain Drug-Induced An\u00e6mias","author":"GROSS R. T.","year":"1958"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1960.9.3.237"},{"key":"e_1_2_1_17_1","first-page":"217","article-title":"A Modification of the Nitroprosside Method of Analysis for Glutathione","volume":"30","author":"GRUNERT R. R.","year":"1951","journal-title":"Arch. Biochem."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1957.tb60065.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1959.8.2.98"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V17.4.418.418"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1952.1.2.180"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)92819-1"},{"key":"e_1_2_1_23_1","first-page":"205","article-title":"L'individualita bio-enzimatica dell 'eritrocito \u2018Fabico\u2019 sopra alcune anomalie biochimiche ed enzimatiche delle emazie nei pazienti affetti da favismo e nei loro familiari","volume":"43","author":"LARIZZA P.","year":"1958","journal-title":"H\u0153matologica"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","unstructured":"LEE C TINK A. ROBIN H. andHARLEY J.(1961) \u201cNeonatal Jaundice Two Cases Associated with Glucose-6-Phosphate Dehydrogenase Deficiency in Erythrocytes\u201d Med. J. Aust. in the press.","DOI":"10.5694\/j.1326-5377.1961.tb69524.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1960.tb68723.x"},{"key":"e_1_2_1_26_1","first-page":"189","article-title":"Hemoglobin Catabolism. I. Glutathione Peroxidase, an Erythrocyte Enzyme which Protects Hemoglobin from Oxidative Breakdown","volume":"229","author":"MILLS G. C.","year":"1957","journal-title":"J. biol. Chem."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1958.tb36443.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1957.tb60208.x"},{"key":"e_1_2_1_29_1","first-page":"695","article-title":"Studies on the Hemolytic Principle of the Fava Bean","volume":"56","author":"ROTH K. L.","year":"1960","journal-title":"J. Lab. clin. Med."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)91028-X"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1182\/blood.V13.4.348.348","article-title":"Studies on Glutathione Stability in Erythrocytes of Cases with Past History of Favism or Sulfa-Drug-Induced Hemolysis","volume":"13","author":"SZEINBERG A.","year":"1958","journal-title":"Blood"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V13.11.1043.1043"},{"key":"e_1_2_1_33_1","unstructured":"SZEINBERG A. andSHEBA C.(1959) \u201cHemolytic Trait in Non-Ashkenazic Jews Connected with a Hereditary Enzymatic Abnormality of Erythrocytes\u201d Quart. Rev. Harefuah 1959 No. 3."},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1542\/peds.23.1.18","article-title":"An In Vitro Abnormality of Glutathione Metabolism in Erythrocytes from Normal Newborns: Mechanism and Clinical Significance","volume":"23","author":"ZINKHAM W. H.","year":"1959","journal-title":"Pediatrics"}],"container-title":["Australasian Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.1961.10.3.192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.1961.10.3.192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:14:10Z","timestamp":1697001250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.1961.10.3.192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1961,8]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1961,8]]}},"alternative-id":["10.1111\/imj.1961.10.3.192"],"URL":"https:\/\/doi.org\/10.1111\/imj.1961.10.3.192","archive":["Portico"],"relation":{},"ISSN":["0571-9283"],"issn-type":[{"value":"0571-9283","type":"print"}],"subject":[],"published":{"date-parts":[[1961,8]]}}}