{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:07:21Z","timestamp":1762067241371},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":20133,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1962,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A review has been made of certain clinical features of the episodes of \u201clate\u201d neonatal jaundice sustained by five infants, who appeared to be either hemizygous or heterozygous for the gene responsible for an erythrocytic defect of the enzyme glucose\u20106\u2010phosphate dehydrogenase (G6PD). Each of these infants seemed well on discharge from the obstetric hospital, but was subsequently readmitted to hospital as a result of the appearance of jaundice. The age of onset of these episodes ranged from 10 to 23 days.<\/jats:p><jats:p>Four infants were males of Italian extraction, with erythrocytes grossly deficient in G6PD activity. Each was receiving maternal breast milk over the period preceding the onset of jaundice. One mother was concurrently taking phenacetin and acetylsalicylic acid, and another was receiving sulphamethoxypyridazine for a mild urinary tract infection. One male infant was found to be suffering from an inflamed umbilicus, from which Escherichia coli was grown on culture, at the same time as the episode of jaundice.<\/jats:p><jats:p>Subsequently, each of the four males developed an\u00e6mia, with or without evidence of excessive haemolysis; possible \u00e6tiological factors included Vicia fava, chloramphenicol, sulphamethoxypyridazine and bacterial or viral infections. Two brothers were found to have hypochromic microcytic an\u00e6mia, which appears to be responding to oral iron therapy; radiological evidence of cholelithiasis was demonstrated, at the age of 22 years, in the G6PD\u2010deficient mother of these brothers.<\/jats:p><jats:p>The fifth infant was a female of Maltese extraction. The G6PD activity was within the normal range in the child, but very low in her father's erythrocytes. In this infant, jaundice of mild degree was accompanied by evidence of slightly increased h\u00e6molysis, and persisted for approximately 13 weeks.<\/jats:p><jats:p>These episodes of neonatal jaundice have been discussed in terms of current concepts of the clinical significance of G6PD deficiency, with emphasis on the interrelations between the syndromes which may occur in individuals with enzyme\u2010deficient erythrocytes.<\/jats:p>","DOI":"10.1111\/imj.1962.11.3.148","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T14:31:12Z","timestamp":1505399472000},"page":"148-155","source":"Crossref","is-referenced-by-count":9,"title":["\u201cLATE\u201d NEONATAL JAUNDICE IN INFANTS WITH GLUCOSE\u20106\u2010PHOSPHATE DEHYDROGENASE\u2010DEFICIENT ERYTHROCYTES"],"prefix":"10.1111","volume":"11","author":[{"given":"JOHN D.","family":"HARLEY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELEN","family":"ROBIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0021-9258(18)71192-7","article-title":"The Quantitative Significance of Glycolysis and Non-Glycolysis in Glucose Utilization by Rat Mammary Gland","volume":"211","author":"ABRAHAM S.","year":"1954","journal-title":"J. biol. 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