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This lesion is accompanied by a decrease of enzyme activity in this region, particularly for alkaline phosphatase and lactate dehydrogenase, and changes in the amounts of these enzymes present have been followed by histochemical and biochemical techniques. The progress of lesions of differing severity in rats was followed at intervals for a period of seven weeks. By this time, tubular regeneration was occurring, and, except in a few focal areas, enzymic activity had almost returned to normal. Renal toxicity was also demonstrated after very large oral doses of neomycin. Certain similarities in the responses of the alimentary and renal epithelia to neomycin were demonstrated.<\/jats:p>","DOI":"10.1111\/imj.1964.13.2.149","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T14:31:16Z","timestamp":1505399476000},"page":"149-156","source":"Crossref","is-referenced-by-count":2,"title":["STUDIES ON THE NEPHROTOXIC EFFECT OF NEOMYCIN"],"prefix":"10.1111","volume":"13","author":[{"given":"B. 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