{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:42:30Z","timestamp":1760042550299,"version":"3.41.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":18673,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1966,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The case history is reported of a male chronic alcoholic, aged 40 years, who presented with muscle cramps and weakness, the passage of a decreasing quantity of dark urine, and a past history of similar episodes, all of which followed periods of acute alcoholism. The diagnosis of rhabdomyolysis was confirmed by the demonstration of myoglobinuria and the histological findings in skeletal muscle. Management of the accompanying hyperkal\u00e6mia and acute renal failure was by a potassium\u2010binding resin and mannitol diuresis.<\/jats:p><jats:p>Physiological studies of forearm skeletal muscle revealed a decreased exercise ability, but a normal vascular and biochemical response to exercise and intra\u2010arterial infusion of adrenaline. Intra\u2010arterial infusion of alcohol caused a decrease in the blood flow through forearm muscle.<\/jats:p><jats:p>Electron microscopic examination of skeletal muscle obtained during the acute attack revealed patchy cellular and mitochondrial damage. The latter appeared to precede myofibrillar damage, as normal myofibrils were found adjacent to injured mitochondria; but normal mitochondria were not found adjacent to damaged myofibrils.<\/jats:p><jats:p>Without information about the degree of muscle isch\u00e6mia produced by alcohol or about the effects of isch\u00e6mia on the ultrastructure of skeletal muscle cells, it is not possible at present to determine whether rhabdomyolysis is caused by isch\u00e6mia or by some other mechanism.<\/jats:p>","DOI":"10.1111\/imj.1966.15.3.251","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T07:50:23Z","timestamp":1505461823000},"page":"251-261","source":"Crossref","is-referenced-by-count":14,"title":["RECURRENT RHABDOMYOLYSIS PRECIPITATED BY ALCOHOL: A CASE REPORT WITH PHYSIOLOGICAL AND ELECTRON MICROSCOPIC STUDIES OF SKELETAL MUSCLE"],"prefix":"10.1111","volume":"15","author":[{"given":"R. M.","family":"DOUGLAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"FEWINGS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"CASLEY-SMITH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"WEST","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007226"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1939.sp003789"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-6-1133"},{"key":"e_1_2_1_5_1","unstructured":"CASLEY-SMITH J. 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A propos de 2 observations","volume":"71","author":"LARCAN A.","year":"1963","journal-title":"Presse m\u00e9d."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.5.361"},{"key":"e_1_2_1_17_1","first-page":"14","article-title":"Myopathy due to a Defect in Muscle Breakdown","volume":"10","author":"MCARDLE B.","year":"1951","journal-title":"Clin. 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