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Plasma volume expansion was found during attacks without gain in overall body weight, consistent with a redistribution of water between cells and extra\u2010cellular fluid.<\/jats:p><jats:p>Oliguria associated with sodium and potassium retention was found during attacks. During recovery, either spontaneous or produced by potassium chloride administration, a marked coincident diuresis of sodium, potassium and water occurred, with the excretion of an alkaline urine. Failure to demonstrate any reciprocity between sodium reabsorption and potassium and hydrogen ion excretion during oliguria or mannitol\u2010induced sodium diuresis, suggests that the site of sodium reabsorption is proximal to the distal convoluted tubule. The rate of excretion of aldosterone fell as paralysis increased, coinciding with the time of plasma volume expansion.<\/jats:p>","DOI":"10.1111\/imj.1966.15.4.352","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T07:50:30Z","timestamp":1505461830000},"page":"352-358","source":"Crossref","is-referenced-by-count":6,"title":["STUDIES IN FAMILIAL HYPOKAL\u00c6MIC PERIODIC PARALYSIS"],"prefix":"10.1111","volume":"15","author":[{"given":"J. F.","family":"NIALL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"PAK POY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"47","article-title":"Observations on a Case of Familial Periodic Paralysis","volume":"3","author":"AITKEN R. S.","year":"1937","journal-title":"Clin. 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