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The basal studies include the measurement of the total 17\u2010oxogenic steroid content in the urine, total pituitary gonadotrophin content in the urine, thyroidal uptake of <jats:sup>131<\/jats:sup>I and serum growth hormone levels. The stimuli used include insulin\u2010induced hypoglyc\u00e6ia and the administration of metyrapone, pyrogens and vasopressin. The majority of patients with hypopituitarism have partial hypopituitarism, and unihormonal deficiencies are not uncommon. Classification of the disorder should be on a functional basis.<\/jats:p>","DOI":"10.1111\/imj.1967.16.2.107","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T08:05:18Z","timestamp":1505462718000},"page":"107-113","source":"Crossref","is-referenced-by-count":5,"title":["THE INVESTIGATION OF HYPOPITUITARISM"],"prefix":"10.1111","volume":"16","author":[{"given":"L.","family":"LAZARUS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)91136-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-395715-3.50017-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-16-8-1059"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90190-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196412312712701"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-11-1470"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-59-3-293"},{"key":"e_1_2_1_9_1","first-page":"241","article-title":"The Regulation of Growth Hormone Secretion","volume":"21","author":"GLICK S. 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