{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:55:10Z","timestamp":1699703710885},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":18308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1967,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Red cell survival was determined in 20 patients with idiopathic unconjugated hyperbilirubin\u00e6mia without overt signs of h\u00e6molysis (Gilbert's syndrome) by means of a double isotope technique with the use of diisopropylfluorophosphate (DF<jats:sup>32<\/jats:sup>P) and chromium (<jats:sup>51<\/jats:sup>Cr) simultaneously. Red cell life span was significantly reduced in 42% of patients. However, the degree of h\u00e6molysis was not sufficient to produce hyperbilirubin\u00e6mia in persons with normal hepatic function. The incidence of familial involvement in patients with reduced red cell survival was not significantly different from that in patients with normal red cell survival. Similarly, there was no difference between the groups with respect to symptomatology, age of onset of jaundice, or results of laboratory investigations.<\/jats:p><jats:p>It is concluded that the hyperbilirubin\u00e6mia in this syndrome is more likely to be due to a defect in hepatic handling of bilirubin than to compensated h\u00e6molysis. This defect appears to occur whether or not there is a reduced red cell survival. It remains to be shown why some patients with this syndrome have a reduced red cell survival while others do not.<\/jats:p>","DOI":"10.1111\/imj.1967.16.3.221","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T08:35:16Z","timestamp":1505464516000},"page":"221-225","source":"Crossref","is-referenced-by-count":19,"title":["AN ASSESSMENT OF RED CELL SURVIVAL IN IDIOPATHIC UNCONJUGATED HYPERBILIRUBIN\u00c6MIA (GILBERT'S SYNDROME) BY THE USE OF RADIOACTIVE DIISOPROPYLFLUOROPHOSPHATE AND CHROMIUM"],"prefix":"10.1111","volume":"16","author":[{"given":"L. W.","family":"POWELL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBARA H.","family":"BILLING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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