{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:30:22Z","timestamp":1759541422006},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":17577,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A study has been carried out of the clinical features, epidemiology and thyroid function in 254 cases of endemic cretinism in Eastern New Guinea. The clinical picture resembles closely that described for Western New Guinea and other endemic goitre areas throughout the world.<\/jats:p><jats:p>Goitre was encountered more commonly in mothers of cretins than in adult females of the studied population. Examination of thyroid function revealed a significantly lower serum PBI value and I uptake in cretins when compared with neurologically normal natives. No clinical evidence of hypothyroidism was encountered in endemic cretins, and no biosynthetic defect was isolated as shown by perchlorate discharge testing and chromatography of I131 labelled thyroid glands and serum. Mothers of 13 cretins, born since the introduction of iodized oil prophylaxis, were identified, and in only one instance was there a possibility that iodine therapy had been given.<\/jats:p><jats:p>These findings suggest that the condition is related to iodine deficiency and may be prevented by correction of maternal iodine deficiency.<\/jats:p>","DOI":"10.1111\/imj.1969.18.3.217","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T09:05:14Z","timestamp":1505466314000},"page":"217-221","source":"Crossref","is-referenced-by-count":4,"title":["ENDEMIC CRETINISM IN EASTERN NEW GUINEA"],"prefix":"10.1111","volume":"18","author":[{"given":"I. H.","family":"BUTTFIELD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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F.","year":"1963","journal-title":"Med. J. Aust."},{"key":"e_1_2_1_17_1","article-title":"The Thyroid and its Diseases","author":"MEANS J. H.","year":"1963","journal-title":"McGraw Hill, New York, London."},{"key":"e_1_2_1_18_1","article-title":"Endemic goiter","author":"PEREZ C.","year":"1960","journal-title":"WHO, Geneva."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)90233-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-16-11-1522"},{"key":"e_1_2_1_21_1","first-page":"649","article-title":"Distribution of Goitre in United Provinces: Further Notes on the Aetiology of Goitre in Super-endemic Areas of the Gonda and Gorakhpur Districts","volume":"21","author":"STOTT H.","year":"1934","journal-title":"Ind J. 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