{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:06:03Z","timestamp":1761419163725},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":17393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1970,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Normal subjects were given a constant infusion of secretin and consecutive 5\u2010minute samples of duodenal aspirate were collected. Tests in which bile was present in duodenal aspirate were discarded. In 8 subjects, intravenous alcohol caused a significant reduction in volume without a fall in bicarbonate concentrations. In 3 subjects, intravenous dextrose did not cause a fall in volumes of aspirate. These findings indicate that intravenous alcohol causes obstruction to pancreatic outflow, presumably as a result of contraction of the sphincter of Oddi<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#imj197019124-note-0003\" \/>.<\/jats:p><jats:p>In view of the functional and anatomical connections between the duodenal and sphincteric musculature, the effects of intravenous alcohol on duodenal motility were studied by combined electromanometric and cineradiologic techniques. Intravenous alcohol in eleven normal subjects caused a significant increase in duodenal motility, whereas intravenous dextrose had no effect.<\/jats:p><jats:p>It is postulated that alcohol has a systemic effect leading to obstruction to pancreatic outflow and that this is one factor in the production of alcoholic pancreatitis.<\/jats:p>","DOI":"10.1111\/imj.1970.19.1.24","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T08:55:47Z","timestamp":1505465747000},"page":"24-29","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Intravenous Alcohol on Motility of the Duodenum and of the Sphincter of Oddi"],"prefix":"10.1111","volume":"19","author":[{"given":"R. C.","family":"Pirola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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