{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T01:38:47Z","timestamp":1699580327865},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":17212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australasian Annals of Medicine"],"published-print":{"date-parts":[[1970,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Three groups of laboratory tests were assessed for possible clinical application in the diagnosis of rheumatic carditis.<\/jats:p><jats:p>Serum antibody cross\u2010reactive with human myocardium and group A streptococcal cell membrane (heart\u2010reactive antibody\u2014H.R.A.) was found in titres above the normal range in most patients with post\u2010streptococcal carditis, arthritis or glomerulonephritis and less often in patients with surgical myocardial damage. Patients with acute rheumatic carditis had lower titres on admission than those with acute rheumatic arthritis alone; after treatment titres rose in the carditis group but fell in children with arthritis. These findings suggested a possible pathogenic role for this antibody in rheumatic carditis, and suggest its determination to be useful in diagnosis.<\/jats:p><jats:p>Serum levels of glutamic oxaloacetic transaminase, lactic dehydrogenase and creatine phosphokinase were significantly higher in children with cardiac damage and in those with high titres of H.R.A., but the differences were not sufficiently great to be of clinical value.<\/jats:p><jats:p>Relative increases in the fast\u2010migrating isoenzyme of serum lactic dehydrogenase were found in patients with carditis, and its determination is considered to be of potential clinical value.<\/jats:p>","DOI":"10.1111\/imj.1970.19.3.215","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T09:05:20Z","timestamp":1505466320000},"page":"215-219","source":"Crossref","is-referenced-by-count":1,"title":["Heart\u2010Reactive Antibody, Serum Enzymes and Isoenzymes in the Diagnosis of Acute Rheumatic Fever"],"prefix":"10.1111","volume":"19","author":[{"given":"D. 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