{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:46:43Z","timestamp":1787636803036,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sputum microbiology is an integral aspect of managing patients with bronchiectasis. Adult Aboriginal Australians have a high bronchiectasis disease burden; however, as yet\u00a0there is sparce literature detailing the sputum microbiology profile in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the sputum microbiology profile among Aboriginal patients aged \u226518\u2009years with chest computed tomography\u2010confirmed bronchiectasis in the Top End Northern Territory of Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All available sputum samples processed in a single laboratory service with established protocols for examining and reporting sputum microbiology results between 2011 through 2020 were assessed in relation to demographics, lung function parameters, chest radiology, inhaled pharmacotherapy, hospital admissions restricted to respiratory conditions and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred twenty\u2010eight patients (median age 47\u2009years, 56% female) had sputum cultures available to assess. <jats:italic>Haemophilus spp.<\/jats:italic> was the most common (64%), followed by yeast\/<jats:italic>Candida<\/jats:italic> <jats:italic>spp.<\/jats:italic> (53%) and <jats:italic>Pseudomonas spp.<\/jats:italic> (36%). Polymicrobial cultures were noted in 92% of patients. There were significant geographic differences on a region\u2010wise and community\u2010wise basis. Patients with yeast\/<jats:italic>Candida<\/jats:italic> <jats:italic>spp.<\/jats:italic> and <jats:italic>Pseudomonas spp.<\/jats:italic> recorded more hospitalisations (median 7 (interquartile range (IQR) 3\u201314) and 8 (IQR 4\u201316)). In multivariate models, both yeast\/<jats:italic>Candida<\/jats:italic> <jats:italic>spp.<\/jats:italic> (odds ratio (OR) 2.63 (95% confidence interval (CI) 1.68\u20134.14)) and <jats:italic>Pseudomonas spp.<\/jats:italic> (OR 1.95 (95% CI 1.25\u20133.04)) were associated with increased odds for mortality. Other than higher <jats:italic>Pseudomonas<\/jats:italic> <jats:italic>spp.<\/jats:italic> isolated with the use of inhaled corticosteroids, no significant association was observed either with lung function or chest radiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adult Aboriginal Australians with bronchiectasis harbour a significant microorganism load that may play a role in overall morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.70020","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:03:12Z","timestamp":1741694592000},"page":"784-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sputum microbiology data and related clinical outcomes among adult Aboriginal Australians with bronchiectasis"],"prefix":"10.1111","volume":"55","author":[{"given":"Claire","family":"Gibbs","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"},{"name":"Flinders University College of Medicine and Public Health  Darwin Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-0376","authenticated-orcid":false,"given":"Timothy","family":"Howarth","sequence":"additional","affiliation":[{"name":"Darwin Respiratory and Sleep Health Darwin Private Hospital  Darwin Northern Territory Australia"},{"name":"Department of Technical Physics University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudharsan","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Flinders University College of Medicine and Public Health  Darwin Northern Territory Australia"},{"name":"Department of Infectious Diseases Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-3668","authenticated-orcid":false,"given":"Sanjana S.","family":"Heraganahally","sequence":"additional","affiliation":[{"name":"Division of Medicine The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asanga","family":"Abeyaratne","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin Northern Territory Australia"},{"name":"Department of Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-7137","authenticated-orcid":false,"given":"Subash S.","family":"Heraganahally","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"},{"name":"Flinders University College of Medicine and Public Health  Darwin Northern Territory Australia"},{"name":"Darwin Respiratory and Sleep Health Darwin Private Hospital  Darwin Northern Territory Australia"},{"name":"School of Medicine Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0042-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2022.09.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0638-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194542"},{"key":"e_1_2_8_7_1","unstructured":"Statistics ABo. 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