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These drugs are frequently included in \u2018sick day rules\u2019 and may be prematurely discontinued during acute illness or acute kidney injury (AKI). However, these medications offer substantial benefits, such as preserving cardiac and kidney function and reducing mortality. Discontinuing them without appropriate clinical judgement can lead to unintended harm. Clinicians should adopt a patient\u2010specific, evidence\u2010based approach when managing medications in AKI and chronic kidney disease, informed by pharmacology and individualised risk assessment. Patients may overinterpret advice to \u2018stop nephrotoxic medications\u2019 as a permanent measure, leading to hesitation in restarting necessary treatments. This misconception can create barriers to optimal care and complicate decision\u2010making, as patients may prioritise avoiding perceived harm over addressing their full medical needs. This manuscript emphasises the need for nuanced and informed decision\u2010making in the management of medications in kidney\u2010related conditions.<\/jats:p>","DOI":"10.1111\/imj.70060","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:44:37Z","timestamp":1745322277000},"page":"1037-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The \u2018nephrotoxins\u2019 were stopped: what is in a name and its impact on kidney and cardiac health?"],"prefix":"10.1111","volume":"55","author":[{"given":"Catherine","family":"Mao","sequence":"first","affiliation":[{"name":"Nephrology and Transplantation Unit John Hunter Hospital  Newcastle New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales 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