{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:47:37Z","timestamp":1778006857322,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2019\/GNT1177719"],"award-info":[{"award-number":["2019\/GNT1177719"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allogeneic stem cell transplantation (alloSCT) is an established potentially curative therapy for patients with high\u2010risk chronic lymphocytic leukaemia (CLL). Future availability of chimeric antigen receptor T\u2010cell therapies and bispecific antibodies may further reduce utilisation of alloSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective analysis sought to describe institutional outcomes for alloSCT for CLL, to which future outcomes following immunotherapies may be compared locally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CLL in the institutional alloSCT database were identified. Kaplan\u2013Meier estimates were used to assess survival outcomes, and Gray's competing incidence analyses were used for cumulative incidence of relapse (CIR) and non\u2010relapse mortality (NRM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients with CLL of median age 54\u2009years (range 25\u201375), including 17 with prior Richter transformation, underwent alloSCT between 2000 and 2022. A total of 39% and 35.4% of tested patients harboured complex karyotype and del(17p) respectively. Median follow\u2010up for survivors was 9.2\u2009years. Two\u2010year progression\u2010free survival (PFS), overall survival (OS), CIR and NRM rates were 57.7%, 74%, 16.3% and 18.2% respectively. Ten\u2010year PFS and OS were 38.2% and 50.8% respectively. Twenty\u2010nine deaths occurred during follow\u2010up, including 14 without prior CLL relapse. Del(17p) abnormality was associated with inferior PFS, and age \u226554\u2009years at alloSCT was associated with inferior OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival outcomes from this study align with prospective and retrospective data published from the chemoimmunotherapy era of CLL treatment. Although more recent data suggest improved post\u2010alloSCT survival outcomes, data assessing the impact of novel agents distinct from improved alloSCT care are lacking. Our recommendations for the current role of alloSCT in CLL therapy are summarised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.70124","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T14:00:01Z","timestamp":1750428001000},"page":"1316-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A single\u2010institution study of allograft outcomes for chronic lymphocytic leukaemia over 20\u2009years"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-4536","authenticated-orcid":false,"given":"Rory","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Royal Melbourne Hospital &amp; Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Frawley","sequence":"additional","affiliation":[{"name":"Department of Clinical 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