{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:31:13Z","timestamp":1792693873876,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Prior reports show the occurrence of moyamoya angiopathy in the ethnically diverse South Auckland region, but little is known about the sociodemographic burden of the condition and clinical outcomes.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To determine the disease prevalence, age, sex and ethnic distribution, management and patient outcomes in adults residing in South Auckland (population 567\u2009000). We also sought to determine associations with the outcomes of vascular events and functional independence following diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We searched hospital medical records and radiology reports dating from 2008 to 2024 for the region using relevant ICD codes and the word \u2018moyamoya\u2019. We used descriptive statistics and local population data to calculate point prevalence as of 19 September 2024. Statistical tests of association were performed for continuous, categorical and time\u2010to\u2010event data for the prespecified outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified 49 patients with a total of 300 patient\u2010years of follow\u2010up. The point prevalence ranged from 4\/100\u2009000 in NZ Europeans and Asian people to 10\/100\u2009000 in M\u0101ori and 14\/100\u2009000 in Pacific Islanders. The mean age at diagnosis was 37 (standard deviation 16) years and females outnumbered males by 3:1. One\u2010quarter had a vascular event within a median of 457\u2009days from diagnosis and two\u2010thirds of the overall cohort were independent on follow\u2010up. Factors associated with a loss of independence included stroke\/transient ischaemic attack (TIA) during follow\u2010up, bilateral disease and severe hypoperfusion on imaging. The mortality rate was 14%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this New Zealand\u2010based study, we found a wide ethnic variation in the prevalence of moyamoya angiopathy and an elevated early risk of TIA and stroke following diagnosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.70209","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:00:45Z","timestamp":1758715245000},"page":"1846-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Demographic, imaging and disease patterns of moyamoya angiopathy in\n South Auckland<\/scp>\n : an observational study from electronic health records"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-6470","authenticated-orcid":false,"given":"Karim","family":"Mahawish","sequence":"first","affiliation":[{"name":"Stroke Department Middlemore Hospital Auckland New Zealand"},{"name":"National Institute for Stroke and Applied Neurosciences Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Anson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-3330","authenticated-orcid":false,"given":"Annemarei","family":"Ranta","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Otago Wellington New Zealand"},{"name":"Department of Neurology Wellington Hospital Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-2083","authenticated-orcid":false,"given":"Rita","family":"Krishnamurthi","sequence":"additional","affiliation":[{"name":"National Institute for Stroke and Applied Neurosciences Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00165-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231216037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-017-0680-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000443"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016670"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis"},{"key":"e_1_2_8_9_1","unstructured":"Te Whatu Ora.Statistics provided by Stats NZ. Accessed 15 May 2025.https:\/\/tewhatuora.shinyapps.io\/populations-web-tool\/."},{"key":"e_1_2_8_10_1","unstructured":"webcoordinator@msd.govt.nz.Improving how we report ethnicity. MSD. Cited 2023 Feb 20.https:\/\/www.msd.govt.nz\/about-msd-and-our-work\/tools\/how-we-report-ethnicity.html."},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"VandenbrouckeJP PocockSJ PooleC SchlesselmanJJ EggerM.Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration. Ann Intern Med. 2007; 147: W\u2010163\u2013W\u2010194.","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1"},{"key":"e_1_2_8_12_1","first-page":"281","article-title":"Moyamoya disease in a young woman with intra\u2010 and extracranial vessels involvement on vessel wall imaging","volume":"24","author":"Toh TH","year":"2019","journal-title":"Neurol Asia"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2021.11.PEDS21384"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107770"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2021-0382"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2024.4.JNS2419"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.03.146"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022628"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007819"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T15:10:08Z","timestamp":1762960208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/imj.70209"],"URL":"https:\/\/doi.org\/10.1111\/imj.70209","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"2024-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}