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We report five cases of newly diagnosed severe AAV treated with combination cyclophosphamide and rituximab, with the goal of ceasing GCs within 4\u2009weeks. All patients achieved complete remission, with one relapse during follow\u2010up. All remained GC\u2010free at a median follow\u2010up of 12 months. The regimen was well tolerated despite severe renal impairment. These findings support the feasibility of early GC withdrawal in organ\u2010threatening AAV.<\/jats:p>","DOI":"10.1111\/imj.70212","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T14:54:17Z","timestamp":1758552857000},"page":"1939-1943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early glucocorticoid withdrawal in severe\n                    <scp>ANCA<\/scp>\n                    \u2010associated vasculitis treated with combination cyclophosphamide and rituximab: a single\u2010centre case series"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-168X","authenticated-orcid":false,"given":"Tania","family":"Salehi","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"The University of Adelaide  Adelaide South Australia 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 Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0204-y"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.008"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21984"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803537"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.6615"},{"key":"e_1_2_4_7_1","first-page":"260","article-title":"A novel glucocorticoid\u2010free maintenance regimen for anti\u2010neutrophil cytoplasm antibody\u2010associated vasculitis","volume":"58","author":"Pepper RJ","year":"2019","journal-title":"Rheumatology 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