{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:39:36Z","timestamp":1773949176672,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gaucher disease (GD) has been variably associated with cancer risk, with conflicting reports in the literature. Understanding the true cancer burden is critical for patient care and genetic counselling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the overall and site\u2010specific cancer risk in a large, single\u2010centre GD cohort over three decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study based at a national referral centre. Medical records of 709 GD patients aged &gt;20\u2009years at Shaare Zedek Medical Center were reviewed. Cancer diagnoses were confirmed using the Israel National Cancer Register. Cancer\u2010free survival was estimated via Kaplan\u2013Meier analysis. Standardised incidence ratios (SIRs) compared observed versus expected cancer cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010four (9%) patients were diagnosed with cancer. The most common malignancies were breast, non\u2010Hodgkin lymphoma (NHL) and colon cancer. The overall incidence was 3.7 (95% confidence interval (CI): 2.6\u20134.8) per 1000 person\u2010years. Cancer risk correlated with age but not gender, genotype, splenectomy status or GD therapy. The overall SIR was 0.9 (95% CI: 0.6\u20131.1), indicating no increased overall cancer risk. However, SIRs for haematological malignancies, including NHL and multiple myeloma, were elevated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GD patients do not have an increased general cancer risk, though vigilance for haematological malignancies is warranted. Previous literature might have overestimatee risk due to selection bias. These findings support tailored screening strategies and may alleviate patient concerns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70221","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:17:49Z","timestamp":1758881869000},"page":"1859-1866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A large long\u2010term database of Gaucher disease patients demonstrates increased risk of lymphoma and myeloma, but not of solid tumours"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-2828","authenticated-orcid":false,"given":"Majdolen","family":"Istaiti","sequence":"first","affiliation":[{"name":"Gaucher Unit The Eisenberg R&amp;D Authority, Shaare Zedek Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-5644","authenticated-orcid":false,"given":"Tama","family":"Dinur","sequence":"additional","affiliation":[{"name":"Gaucher Unit The Eisenberg R&amp;D Authority, Shaare Zedek Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ora","family":"Paltiel","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine Hebrew University  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Silverman","sequence":"additional","affiliation":[{"name":"The Israel National Cancer Register (INCR), Ministry of Health  Jerusalem 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