{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:20:40Z","timestamp":1770891640042,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Schnitzler syndrome is a rare autoinflammatory syndrome caused by a dysregulation of the interleukin\u20101\u03b2 signalling pathway. Symptoms tend to appear in middle age and include urticariform skin lesions, fever, bone pain, lymphadenopathy and IgM monoclonal gammopathy. Interleukin\u20101 (IL\u20101) targeted therapy constitutes the basis for treatment and can lead to complete resolution of symptoms. We report a case of Schnitzler syndrome in a 49\u2010year\u2010old man refractory to anakinra and subsequently treated successfully with canakinumab.<\/jats:p>","DOI":"10.1111\/imj.70233","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:22:01Z","timestamp":1770196921000},"page":"306-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Canakinumab as effective therapy in anakinra\u2010refractory Schnitzler syndrome: a case\u2010based review"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-6263","authenticated-orcid":false,"given":"Sergio","family":"De Santos Belinch\u00f3n","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Aus\u00edn Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Institute of Health Research  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4496-6718","authenticated-orcid":false,"given":"Pablo Daniel","family":"Lorenzo Barcia","sequence":"additional","affiliation":[{"name":"Department of Emergency Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Pire Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Balastegui Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Immunology Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Mu\u00f1oz Delgado","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Victoria","family":"Villalba Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Institute of Health Research  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8607","authenticated-orcid":false,"given":"Cristina","family":"Lavilla Olleros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Institute of Health Research  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"SchnitzlerL.L\u00e9sions urticariennes chroniques permanentes (\u00e9ryth\u00e8me p\u00e9talo\u00efd?).J Dermatol Angers1972."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200101000-00004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-41"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08251.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07417.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(05)81424-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3703"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez448"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12129"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13035"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0673-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem048"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.06.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202192"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.70233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:22:17Z","timestamp":1770888137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/imj.70233"],"URL":"https:\/\/doi.org\/10.1111\/imj.70233","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}