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A comprehensive literature search was performed using\n                    <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>\n                    , prioritising randomised controlled trials and notable observational studies since 2011. Hospital antimicrobial stewardship programmes can significantly improve neutropenic fever care through personalised approaches and decision support tools which consider individual risk profiles, colonisation status and infection history to guide precise empiric therapy decisions. Key aspects include pre\u2010chemotherapy antibiotic allergy assessments, appropriate use of cephalosporins in certain allergy cases, and specialised evaluation for severe reactions. The microbiology laboratory plays a crucial role in pathogen diagnosis and surveillance for drug resistance including formulation of antibiograms. Infection prevention and control measures, including adherence to national standards and local protocols, are critical in reducing hospital\u2010acquired infections. Optimised antimicrobial dosing should be implemented, considering patient\u2010specific factors and utilising therapeutic drug monitoring. Advanced practice nurses can significantly contribute to patient experience through direct management and education. The management of NF requires a cohesive hospital\u2010wide strategy that goes beyond the actions of individual clinicians and draws on the collective expertise of various disciplines. 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