{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:13:40Z","timestamp":1765811620037,"version":"3.48.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Convalscent plasma (CP) was identified as a potential therapy for COVID\u201019 available early in the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate CP for the treatment of hospitalised adults with COVID\u201019 within the Australasian COVID\u201019 Trial (ASCOT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ASCOT is an investigator\u2010initiated, international, open\u2010label, randomised clinical trial. Adult patients hospitalised with confirmed SARS\u2010CoV\u20102 within 12\u2009days of symptom onset and not receiving intensive respiratory or vasopressor\/inotropic support were randomised to two units of CP or standard care. The primary outcome was the proportion of participants who died or required intensive respiratory support (invasive or non\u2010invasive ventilation) or vasopressors\/inotropic support in the 28\u2009days after randomisation. The trial steering committee decided to discontinue the study in January 2021 in response to external evidence suggesting the futility of CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between May and November 2020, 33 participants were enrolled from eight sites across Australia and New Zealand. At baseline, nine (53%) in standard care and seven (47%) in CP arms required supplemental oxygen, three participants (all in the CP arm) required non\u2010invasive ventilation or high\u2010flow oxygen and over half were taking dexamethasone. The primary outcome was met by 23.5% (4\/17) of standard care and 7% (1\/15) of CP participants. One serious adverse event was reported in the CP arm, which was deemed not treatment\u2010related.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fewer participants allocated to CP died or required new intensive respiratory or vasopressors\/inotropic support in the 28\u2009days after randomisation compared to standard care. However, our trial was stopped early in response to external evidence, and our sample size was small, limiting any definitive conclusions regarding the efficacy or safety of CP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70253","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:29:39Z","timestamp":1763800179000},"page":"2024-2032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Convalescent plasma in hospitalised patients with\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-7185","authenticated-orcid":false,"given":"Zoe","family":"McQuilten","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew V. N.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Institute of Clinical Pathology and Medical Research Westmead Hospital  Sydney New South Wales Australia"},{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services NSW Health Pathology  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Purcell","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peta","family":"Edler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria 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