{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:23:04Z","timestamp":1770891784049,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes (T2D). Early treatment can prevent kidney damage, reduce mortality and hospitalisations and delay progression to end\u2010stage kidney disease. While albuminuria screening identifies some at\u2010risk individuals, additional tools are needed to stratify risk in those with normal or moderately increased albuminuria and enable timely use of renoprotective therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the potential impact of PromarkerD, a biomarker\u2010based blood test that predicts CKD risk, on T2D management by Australian clinicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A web\u2010based survey was conducted among general practitioners, endocrinologists, nephrologists and diabetologists to understand current management of patients with T2D and early\u2010stage CKD (estimated glomerular fitration rate\u00a0\u226560 mL\/min per 1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      and normal or moderately increased albuminuria). Clinicians assessed the utility of a validated predictive CKD test and its influence on treatment decisions. The survey introduced the clinical evidence supporting PromarkerD but blinded respondents to the test's commercial name to reduce bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Responses from 178 clinicians revealed an unmet need for predictive CKD testing in T2D management. PromarkerD testing was associated with earlier treatment initiation in moderate\u2010 and high\u2010risk individuals. Among high\u2010risk patients, clinicians reported increased prescribing of sodium\u2010glucose co\u2010transporter 2 inhibitors (62% vs. 40%), angiotensin\u2010converting enzyme inhibitors (73% vs. 49%), angiotensin receptor blockers (66% vs. 42%) and statins (57% vs. 32%), compared with standard care (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.0001). Moderate\u2010risk individuals also saw smaller but significant increases (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2264\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predictive PromarkerD risk scores could improve CKD prevention in T2D by enabling early intervention and guided treatment strategies, with the potential to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70294","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:35:45Z","timestamp":1765604145000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the potential clinical practice impact of the\n                    <scp>PromarkerD<\/scp>\n                    blood test in people with type 2 diabetes in Australia"],"prefix":"10.1111","volume":"56","author":[{"given":"Lianzhi K.","family":"Chen","sequence":"first","affiliation":[{"name":"Proteomics International  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-0799","authenticated-orcid":false,"given":"Isabella A.","family":"Joubert","sequence":"additional","affiliation":[{"name":"Proteomics International  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ying","family":"Kam","sequence":"additional","affiliation":[{"name":"Proteomics International  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten E.","family":"Peters","sequence":"additional","affiliation":[{"name":"Proteomics International  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pearl Lin","family":"Tan","sequence":"additional","affiliation":[{"name":"Proteomics International  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merlin C.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Diabetes Central Clinical School, Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00499.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.18"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.173"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_8_7_1","volume-title":"Chronic Kidney 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