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TIE patients are a highly heterogeneous population whose biological and chronological age can vary substantially. The treatment of these patients can be challenging in clinical practice and requires a frailty\u2010adapted, individualised approach with an emphasis on treatment deliverability and tolerability to optimise patient outcomes. Here, we summarise recommendations for TIE patients, including pre\u2010treatment considerations, induction and maintenance therapies, and supportive care management.<\/jats:p>","DOI":"10.1111\/imj.70329","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:31:08Z","timestamp":1767871868000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-444X","authenticated-orcid":false,"given":"Shirlene","family":"Sim","sequence":"first","affiliation":[{"name":"Department of Haematology St Vincent's Hospital  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine UNSW Medicine and Health  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Zannettino","sequence":"additional","affiliation":[{"name":"Department of Experimental Haematology University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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