{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:50:49Z","timestamp":1792687849190,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The assessment on whether to escalate care in patients with cirrhosis to the intensive care unit (ICU) is complex, with little data on long\u2010term outcomes. The primary aim of this study was to prospectively examine the ability of liver\u2010specific and ICU prognostic scores to predict 12\u2010month survival among patients with cirrhosis in one non\u2010transplant health service. The secondary aim was to assess the prognostic scores in predicting shorter\u2010term survival and the correlation between other demographic and biochemical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with cirrhosis who had an unplanned admission to the ICU were included in the study prospectively. Patient demographics and biochemical markers were collected, liver\u2010specific and ICU prognostic scores, as well as the Chronic Liver Failure Consortium acute liver failure and acute decompensation scores were calculated. The pre\u2010acute deterioration Child Turcotte Pugh, Model for End\u2010Stage Liver Disease (MELD) and MELD\u2010Na scores from the 1\u20136 months prior to the admission were also obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred patients were included over 33 months, with a median follow\u2010up of 25 months. Sixty percent of patients survived longer than 12 months. Sepsis was the most common cause of cacute on chronic liver failure; (ACLF), which was associated with a lower 30\u2010day survival. Patients with non\u2010variceal gastrointestinal bleeding were more likely to survive 12 months. In patients with ACLF (\n                      <jats:italic>n<\/jats:italic>\n                      =\u200957), the day 1 MELD score was the best at predicting long\u2010term survival, whereas in patients without ACLF, none of the scores performed particularly well, with an area under the receiver operating characteristic curve below 0.6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with cirrhosis may have excellent long\u2010term outcomes following ICU admissions. Distinguishing whether a patient is in ACLF or non\u2010ACLF may aid with determining the appropriate prognostic score to apply to aid decision making on limitations of patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70433","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:40:17Z","timestamp":1782196817000},"page":"1323-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective study of 12\u2010month survival of patients with cirrhosis admitted to intensive care"],"prefix":"10.1111","volume":"56","author":[{"given":"Minnie","family":"Au","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian J","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sern W","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh D","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Oziemski","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-2757","authenticated-orcid":false,"given":"Amanda J","family":"Nicoll","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Melbourne Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.024"},{"key":"e_1_2_10_4_1","volume-title":"When and how to Perform Surveillance. Portal Hypertension VI: Proceedings of the Sixth Baveno Consensus Workshop: Stratifying Risk and Individualizing Care","author":"Majumdar A","year":"2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i10.1341"},{"key":"e_1_2_10_7_1","unstructured":"ChildC TurcotteJ.Surgery and portal hypertension 1964."},{"key":"e_1_2_10_8_1","volume-title":"The Liver and Portal Hypertension","author":"Child C","year":"1964"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801209"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198108000-00008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06914-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198411000-00012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.045"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27849"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0257-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200611"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02842.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.024"},{"key":"e_1_2_10_22_1","first-page":"263","article-title":"Prognostic indicators in patients with liver cirrhosis admitted to an intensive care unit","volume":"20","author":"Castera L","year":"1996","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.466"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i15.1817"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.70433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:42:37Z","timestamp":1786466557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/imj.70433"],"URL":"https:\/\/doi.org\/10.1111\/imj.70433","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}