{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:05:34Z","timestamp":1785229534719,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal transplant is a rare procedure reserved for patients with intestinal failure who cannot be sustained on total parenteral nutrition due to severe, life\u2010threatening complications. This study aims to describe the activity and outcomes of intestinal transplantation undertaken in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational retrospective cohort study of all adult and paediatric patients who have received an intestinal transplant in Australia. The primary outcomes were patient and graft survival, with secondary outcomes including incidence of post\u2010transplant enteral autonomy and post\u2010transplant complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen patients (14 adults, five children) received a total of 20 intestinal transplants in Australia between 2010 and 2026. One\u2010year conditional graft and patient survival was 87% and 93% respectively, with 5\u2010year conditional graft and patient survival rates of 67% and 75% respectively. The median time to cease total parenteral nutrition and achieve enteral autonomy after transplant was 21\u2009days (interquartile range: 17\u201030 days). Median body mass index was within ideal range for adult patients by 12 months post\u2010transplant and growth centiles improved for paediatric patients. Eight patients (40%) experienced a total of 14 episodes of rejection at a median onset of 7.5 months after transplant, of which five were graded severe. Rates of post\u2010transplant lymphoproliferative disorder and graft\u2010versus\u2010host disease were low (5% each).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Australian Intestinal Transplant Service demonstrates excellent patient outcomes, with short\u2010 to medium\u2010term graft and patient survival similar to that of leading international centres and enteral autonomy achieved in all patients. Intestinal transplant is now an acceptable, life\u2010saving procedure in appropriately selected patients in our region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70466","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:35:32Z","timestamp":1778153732000},"page":"1182-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal transplantation in Australia: progress, challenges and future directions"],"prefix":"10.1111","volume":"56","author":[{"given":"Brooke","family":"Chapman","sequence":"first","affiliation":[{"name":"Liver and Intestinal Transplant Unit Austin Health  Melbourne Victoria Australia"},{"name":"Department of Surgery (Austin Precinct) University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Centre for Transplantation Excellence and Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Wong","sequence":"additional","affiliation":[{"name":"Liver and Intestinal Transplant Unit Austin Health  Melbourne Victoria Australia"},{"name":"Department of Surgery (Austin Precinct) University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Centre for Transplantation Excellence and Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Starkey","sequence":"additional","affiliation":[{"name":"Liver and Intestinal Transplant Unit Austin Health  Melbourne Victoria Australia"},{"name":"Department of Surgery (Austin Precinct) University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Centre for Transplantation Excellence and Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Perini","sequence":"additional","affiliation":[{"name":"Liver and Intestinal Transplant Unit Austin Health  Melbourne Victoria Australia"},{"name":"Department of Surgery (Austin Precinct) University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Centre for Transplantation Excellence and Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Testro","sequence":"additional","affiliation":[{"name":"Liver and Intestinal Transplant Unit Austin Health  Melbourne Victoria Australia"},{"name":"Department of Surgery (Austin Precinct) University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Centre for Transplantation Excellence and Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80357-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010172"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2022.151181"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000865"},{"key":"e_1_2_7_7_1","unstructured":"Committee IS. International Intestinal Transplant Registry:2023Update. 2023."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.09.071"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.10605"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intf.2025.100072"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003065"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.06.299"},{"key":"e_1_2_7_13_1","unstructured":"TSANZ.Clinical guidelines for organ transplantation from deceased donors. Australian Government Organ and Tissue Authority;2025. Contract No.: Version 1.15."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000757644.62358.c8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-018-9804-8"},{"key":"e_1_2_7_16_1","unstructured":"International Intestinal Rehabilitation and Transplant RegistryInternational Intestinal Transpant Registry;2025. Available from URL:www.intestinalregistry.org."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13669"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2017.01.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114529446"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2023.04.010"},{"key":"e_1_2_7_21_1","unstructured":"IRTA.International intestinal transplant registry report 2019.2019."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b67725"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15269"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00710.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.043"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.70027"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/14750708.2.6.853"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318265f310"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14654"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12979"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000945776.55579.24"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000757780.40342.ed"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000933"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.023"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b7509c"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2018.01.011"},{"key":"e_1_2_7_37_1","first-page":"229","article-title":"Home parenteral nutrition in Australia: a complex yet under\u2010resourced medical intervention","volume":"38","author":"Wong D","year":"2023","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.70466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:53:03Z","timestamp":1785228783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/imj.70466"],"URL":"https:\/\/doi.org\/10.1111\/imj.70466","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}