{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:34:53Z","timestamp":1786469693611,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Staphylococcus lugdunensis<\/jats:italic>\n                      is a coagulase\u2010negative\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      that has been increasingly recognised as a significant pathogen capable of causing invasive infections similar to\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      . Data comparing the clinical manifestations and outcomes of\n                      <jats:italic>S. lugdunensis<\/jats:italic>\n                      bacteraemia to\n                      <jats:italic>S. aureus<\/jats:italic>\n                      bacteraemia remain limited. This article seeks to compare the two diseases in order to better understand the clinical course of\n                      <jats:italic>S. lugdunensis<\/jats:italic>\n                      bacteraemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to compare the clinical course, management strategies, outcomes and complications of S. lugdunensis and S. aureus bacteraemia in order to better characterise S. lugdunensis bacteraemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study of 57 patients with\n                      <jats:italic>S. lugdunensis bacteraemia<\/jats:italic>\n                      and 66 matched patients with\n                      <jats:italic>S. aureus<\/jats:italic>\n                      bacteraemia across a metropolitan health service in Melbourne, Australia, between 2012 and 2024. Patient demographics, clinical features, biochemical markers, management strategies and outcomes were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline demographics and comorbidities were similar between the groups.\n                      <jats:italic>S. lugdunensis<\/jats:italic>\n                      was more frequently isolated in polymicrobial cultures compared to\n                      <jats:italic>S. aureus<\/jats:italic>\n                      (14\/57 vs 2\/66)\n                      <jats:italic>and<\/jats:italic>\n                      was more frequently viewed as a contaminant by treating clinicians (12\/57 vs 1\/66).\n                      <jats:italic>S. aureus<\/jats:italic>\n                      bacteraemia was associated with longer duration of bacteraemia, and more frequent osteoarticular and spinal epidural infections. However, rates of infective endocarditis were similar between the two groups (9\/57 vs 15\/66), and inpatient and 90\u2010day mortality outcomes were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings support the idea that\n                      <jats:italic>S. lugdunensis<\/jats:italic>\n                      bacteraemia should be approached with similar clinical vigilance as\n                      <jats:italic>S. aureus<\/jats:italic>\n                      , given comparable mortality and potential for serious complications, namely infective endocarditis. Improved clinician awareness is needed to reduce misclassification of\n                      <jats:italic>S. lugdunensis<\/jats:italic>\n                      as contaminants to allow for timely diagnosis and management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70481","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:04:26Z","timestamp":1780765466000},"page":"1385-1393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing clinical manifestations, treatment strategies and outcomes of\n                    <i>Staphylococcus lugdunensis<\/i>\n                    bacteraemia versus\n                    <i>Staphylococcus aureus<\/i>\n                    bacteraemia \u2013 a retrospective cohort 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