{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:13:43Z","timestamp":1789038823261,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","award":["024675 UQMARSH QH"],"award-info":[{"award-number":["024675 UQMARSH QH"]}],"id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["NI2023\u201014"],"award-info":[{"award-number":["NI2023\u201014"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["PhD2022\u201005"],"award-info":[{"award-number":["PhD2022\u201005"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017511","name":"Metro North Hospital and Health Service","doi-asserted-by":"publisher","award":["Stimulus\u2010103\u20102023"],"award-info":[{"award-number":["Stimulus\u2010103\u20102023"]}],"id":[{"id":"10.13039\/100017511","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung cancer is the leading cause of cancer\u2010related deaths worldwide, largely due to late\u2010stage diagnosis. Lung cancer screening by computed tomography (CT) reduces mortality by detecting cancers earlier in high\u2010risk individuals, prompting Australia to launch the National Lung Cancer Screening Program (NLCSP) in 2025. Understanding the differences between screen\u2010detected and clinically diagnosed lung cancers is essential for evaluating the impact of screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare demographic, clinical and treatment characteristics of screen\u2010detected versus clinically diagnosed lung cancer cases in Australia and assess evidence of earlier stage shift and treatment differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Screen\u2010detected cases were sourced from the Queensland Lung Cancer Screening Study (QLCSS) and International Lung Screening Trial (ILST), including cancers identified at baseline CT and up to 5\u2009years of follow\u2010up. Clinically diagnosed cases from the corresponding periods were identified through Queensland Oncology Online. Data included demographics, smoking history, comorbidities, cancer stage and treatments. Wilcoxon rank\u2010sum, Fisher exact and chi\u2010squared tests (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05) were used to compare the groups. Sensitivity analyses included 1:2 case\u2013control and NLCSP\u2010eligible subgroup analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Screen\u2010detected cases were more likely to be diagnosed at stage I (63% vs 28%,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009&lt;\u20090.01) and underwent surgery (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009&lt;\u20090.05), whereas clinically detected cases were mostly stage IV (36% vs 14%) and received more radiotherapy (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009&lt;\u20090.001). These differences persisted in sensitivity and subgroup analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Screen\u2010detected lung cancers show a stage shift towards earlier diagnosis and higher surgical treatment rates, supporting the potential effectiveness of the NLCSP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.70543","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:23:30Z","timestamp":1784780610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Descriptive analysis of screen\u2010detected versus clinically diagnosed lung cancer cases: evidence of earlier stage shift and treatment differences"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6967-8222","authenticated-orcid":false,"given":"Jazmin","family":"Guayco Sigcha","sequence":"first","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-0487","authenticated-orcid":false,"given":"Tian Mun","family":"Chee","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-1993","authenticated-orcid":false,"given":"Ian A.","family":"Yang","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Passmore","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-1403","authenticated-orcid":false,"given":"Kwun M.","family":"Fong","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-8014","authenticated-orcid":false,"given":"Henry M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2005.08.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12864"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000673"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2350"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2011.9020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208655"},{"key":"e_1_2_9_11_1","unstructured":"Cancer Council Australia. MSAC recommendation takes Australia one step closer to a national lung cancer screening program [press release].2022. Accessed September 03 2025. Available from URL:https:\/\/www.cancer.org.au\/about-us\/news-and-media\/media-releases\/msac-recommendation-takes-australia-one-step-closer-to-a-national-lung-cancer-screening-program"},{"key":"e_1_2_9_12_1","unstructured":"Cancer Australia.National lung cancer screening program.2023.Accessed June 02 2025.\u00a0Available from URL:https:\/\/www.canceraustralia.gov.au\/about-us\/lung-cancer-screening"},{"key":"e_1_2_9_13_1","unstructured":"National Cancer Control Indicators.Cancer Australia. Relative survival by stage at diagnosis (lung cancer).2019. Accessed September 03 2025. Available from URL:https:\/\/ncci.canceraustralia.gov.au\/outcomes\/relative-survival-rate\/relative-survival-stage-diagnosis-lung-cancer"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15230"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02789.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201902-102OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009342"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.032698"},{"key":"e_1_2_9_19_1","first-page":"247","article-title":"Lung cancer: diagnosis, staging and treatment","volume":"35","author":"Weaver H","year":"2017","journal-title":"Surgery"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153711"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00249"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611716"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02528"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-20-511"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2019.02.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.11058"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44178-024-00136-2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211776"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz117"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00432-6"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.70543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:00:53Z","timestamp":1789038053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":29,"alternative-id":["10.1111\/imj.70543"],"URL":"https:\/\/doi.org\/10.1111\/imj.70543","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"imj.70543"}}