{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:16:39Z","timestamp":1792844199641,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005890","name":"Hudson Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We describe a patient with sickle cell disease and unexpectedly high bone mineral density. Dual\u2010energy X\u2010ray absorptiometry and high\u2010resolution imaging demonstrated globally increased density with structural heterogeneity, increased porosity and abnormal bone organisation. This suggests altered bone remodelling in sickle cell disease, in which high density may mask impaired bone quality with potential implications for skeletal fragility.<\/jats:p>","DOI":"10.1111\/imj.70557","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:55:14Z","timestamp":1784721314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond osteoporosis in sickle cell disease: high bone mineral density, disorganised bone and fracture risk"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2075-1438","authenticated-orcid":false,"given":"Anusha","family":"Maheshwari","sequence":"first","affiliation":[{"name":"Department of Endocrinology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Metabolic Bone Research Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-9658","authenticated-orcid":false,"given":"Roger","family":"Zebaze","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Milat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Metabolic Bone Research Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Haematology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-0926","authenticated-orcid":false,"given":"Philip","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Metabolic Bone Research Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_4_2_1","article-title":"Sickle cell disease\u2010genetics, pathophysiology, clinical presentation and treatment","volume":"5","author":"Inusa BPD","year":"2019","journal-title":"Int J Neonatal Screen"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/imj.16297","article-title":"Sickle cell 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