{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:45:59Z","timestamp":1785743159877,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (\n AL<\/jats:styled-content>\n ) amyloidosis, or congestive hepatopathy, more typical in transthyretin (\n ATTR<\/jats:styled-content>\n ) amyloidosis. The utility of liver stiffness measurement (\n LSM<\/jats:styled-content>\n ) using FibroScan as a non\u2010invasive alternative to liver biopsy remains uncertain.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To prospectively evaluate the utility of Fibroscan in diagnosing and monitoring for hpeatic infiltratioin in AL and ATTR amyloidosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This pilot prospective study included 14 patients with newly diagnosed amyloidosis at a single centre. Liver involvement was evaluated via FibroScan, liver function tests, liver ultrasound and cardiac biomarkers at baseline and follow\u2010up over 24 months.\n LSM<\/jats:styled-content>\n trends were then descriptively analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Five patients (35.7%) \u2013 three\n ATTR<\/jats:styled-content>\n and two\n AL<\/jats:styled-content>\n amyloidosis \u2013 had baseline\n LSM<\/jats:styled-content>\n >10 kPa, suggestive of increased liver stiffness.\n AL<\/jats:styled-content>\n amyloidosis patients exhibited higher\n LSM<\/jats:styled-content>\n values (>17.3\n kPa<\/jats:styled-content>\n ) despite normal\n ALP<\/jats:styled-content>\n levels.\n LSM<\/jats:styled-content>\n improved in 60% of treated patients. No observable association was found between\n ALP<\/jats:styled-content>\n levels and\n LSM<\/jats:styled-content>\n trends. In\n ATTR<\/jats:styled-content>\n amyloidosis patients,\n LSM<\/jats:styled-content>\n >10\n kPa<\/jats:styled-content>\n was associated with advanced Gilmore stage and elevated\n NT<\/jats:styled-content>\n \u2010\n proBNP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This pilot study suggests\n LSM<\/jats:styled-content>\n may provide a useful early non\u2010invasive adjunct in the assessment of hepatic involvement in amyloidosis; however, it should be interpreted as a non\u2010specific marker. Larger studies are required to validate the diagnostic and prognostic role of FibroScan in this population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.70570","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:07:02Z","timestamp":1785740822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single\u2010centre prospective pilot study"],"prefix":"10.1111","author":[{"given":"M","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Vootukuru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria 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