{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:11:29Z","timestamp":1788595889446,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","award":["CRF\u20105 2024 104428"],"award-info":[{"award-number":["CRF\u20105 2024 104428"]}],"id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>People with cystic fibrosis (pwCF) experience a spectrum of glucose disorders. Spontaneous hypoglycaemia is a unique entity affecting pwCF and can be an incidental finding on biochemistry. Our prospective, single\u2010arm pilot study of eight pwCF without confirmed diabetes and incidental biochemical hypoglycaemia found 62.5% demonstrated fasting or reactive hypoglycaemia on continuous glucose monitoring (CGM). The remaining individuals without hypoglycaemia on CGM demonstrated dysglycaemia consistent with pre\u2010diabetes. Symptomatic spontaneous hypoglycaemia captured on CGM was successfully managed with dietary modifications and dipeptidyl peptidase\u20104 inhibitor in all participants. Whether spontaneous hypoglycaemia precedes progression to pre\u2010diabetes and overt diabetes in pwCF requires further evaluation.<\/jats:p>","DOI":"10.1111\/imj.70626","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:21:13Z","timestamp":1788592873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous glucose monitoring detects spontaneous reactive and fasting hypoglycaemia in cystic fibrosis adults without diabetes"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-2699","authenticated-orcid":false,"given":"Shanal","family":"Kumar","sequence":"first","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Health, Medicine and Behavioural Sciences University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hay","sequence":"additional","affiliation":[{"name":"Biostatistics QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6720-307X","authenticated-orcid":false,"given":"Felicity","family":"Loel","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Nutrition &amp; Dietetics The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-4786","authenticated-orcid":false,"given":"Angela","family":"Matson","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Nutrition &amp; Dietetics The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/pedi.12470","article-title":"Hypoglycemia is common in children with cystic fibrosis and seen predominantly in females","volume":"18","author":"Haliloglu B","year":"2017","journal-title":"Pediatr Diabetes"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1002\/ppul.25081","article-title":"Hypoglycemia in cystic fibrosis during an extended oral glucose tolerance test","volume":"55","author":"Armaghanian N","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/clinem\/dgaa448","article-title":"Hypoglycemia and islet dysfunction following oral glucose tolerance testing in 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prospective study","volume":"104","author":"Shah VN","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.soard.2017.01.025","article-title":"Medical nutrition therapy for post\u2010bariatric hypoglycemia: practical insights","volume":"13","author":"Suhl E","year":"2017","journal-title":"Surg Obes Relat Dis"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.soard.2023.07.008","article-title":"Glycemic variability and hypoglycemia before and after Roux\u2010en\u2010Y gastric bypass and sleeve gastrectomy \u2013 a cohort study of females without diabetes","volume":"20","author":"Nilsen I","year":"2024","journal-title":"Surg Obes Relat Dis"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41366-024-01651-y","article-title":"Incidence and risk factors of post\u2010metabolic and bariatric surgery hypoglycemia: a systematic review","volume":"49","author":"Zheng H","year":"2025","journal-title":"Int J Obes (Lond)"},{"key":"e_1_2_5_11_1","volume-title":"Non\u2010Diabetic Hypoglycemia","author":"Ahmed FW","year":"2023"},{"key":"e_1_2_5_12_1","article-title":"Comparison of continuous glucose monitoring to reference standard oral glucose tolerance test for the detection of dysglycemia in cystic fibrosis: a systematic review","volume":"30","author":"Kumar S","year":"2022","journal-title":"J Clin Transl Endocrinol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1210\/clinem\/dgae626","article-title":"Defining continuous glucose monitor time in range in a large, community\u2010based cohort without diabetes","volume":"110","author":"Spartano NL","year":"2025","journal-title":"J Clin Endocrinol Metabol"}],"container-title":["Internal Medicine 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