{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:13:26Z","timestamp":1776971606144,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg) cells are important in the regulation of immune response, but the exact regulation of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg\u2010cell function <jats:italic>in vivo<\/jats:italic> is still not well known. In the present study, we investigated the functional activity of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells as well as the frequency and number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ox<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>3<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells in the spleens of experimentally infected mice with a tissue\u2010migrating parasite, sparganum (plerocercoid of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pirometra mansoni<\/jats:italic>) for 3\u00a0weeks. The results demonstrated fluctuations in the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg\u2010cell function during the parasite infection, being up\u2010regulated at day 3, down\u2010regulated until day 14, and thereafter up\u2010regulated again at day 21. We also investigated the cytokine\u2010producing capability of the splenocytes to study the pattern of immune response of the mice to the parasite. The results showed decreased capabilities of interleukin\u20102 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102), interferon\u2010\u03b3 (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u03b1 production, whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104\u2010producing and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010\u2010producing capabilities were increased along with the parasitic infection. Meanwhile, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106\u2010producing capability was increased to reach a peak at week 2, and thereafter was decreased to the baseline level. As a regulatory mechanism, we found that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg\u2010cell function was attenuated in the presence of the crude extracts of sparganum, but was enhanced in the presence of the excretory\u2013secretory products, suggesting that sparganum products were involved in the triggering and regulation of immune response in the acute and chronic phases, respectively. Results show that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells are central in the immune homeostasis <jats:italic>in vivo<\/jats:italic> that is maintained by host\u2013parasite interactions during the parasitic infection.<\/jats:p>","DOI":"10.1111\/imm.12017","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:18:48Z","timestamp":1350605928000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Functional changes in regulatory <scp>T<\/scp> cells during an experimental infection with sparganum (plerocercofid of <i><scp>S<\/scp>pirometra mansoni<\/i>)"],"prefix":"10.1111","volume":"138","author":[{"given":"Hyung\u2010Ran","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbiology Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Wha","family":"Won","sequence":"additional","affiliation":[{"name":"Seoul Science High School Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woosung","family":"Lim","sequence":"additional","affiliation":[{"name":"Surgery Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010In","family":"Moon","sequence":"additional","affiliation":[{"name":"Surgery Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jong","family":"Yang","sequence":"additional","affiliation":[{"name":"Parasitology Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Young","family":"Seoh","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ewha Womans University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"201","volume-title":"Regulatory T cells","author":"Jang MH","year":"2011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141122"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.12.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1137"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4180"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0606409"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2089-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm975"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.7147"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6456"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636751"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588423"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.2.3659374"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.3.8351344"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1994.32.2.85"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000076496"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182096008529"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2003.41.2.135"},{"key":"e_1_2_6_21_1","first-page":"222","article-title":"Serological diagnosis of human sparganosis by means of micro\u2010ELISA","volume":"22","author":"Kim H","year":"1984","journal-title":"Kisaengchunghak Chapchi"},{"key":"e_1_2_6_22_1","first-page":"227","article-title":"Component proteins and protease activities in excretory\u2010secretory product of sparganum","volume":"30","author":"Cho SY","year":"1992","journal-title":"Kisaengchunghak Chapchi"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.09.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7274"},{"key":"e_1_2_6_25_1","volume-title":"Cellular and molecular immunology","author":"Abbas AK","year":"2010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.12.1969"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02780.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02739.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00728.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02624.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.02.006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.041749"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.005"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T02:39:19Z","timestamp":1700620759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,13]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/imm.12017"],"URL":"https:\/\/doi.org\/10.1111\/imm.12017","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,13]]},"assertion":[{"value":"2011-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}