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In chronic serum sickness (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>) there are increased deposits of immune complexes in the glomeruli with inflammation and a scarring phenotype. As cucurmin is an effective anti\u2010inflammatory agent and reduces complement activation, we hypothesized that it should alleviate renal disease in this setting. To determine the effectiveness of curcumin, an apoferritin\u2010induced <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> model in Cfh\u2010deficient (Cfh<jats:sup>\u2212\/\u2212<\/jats:sup>) mice was used. Curcumin treatment (30\u00a0mg\/kg) given every day in parallel with apoferritin reduced glomerulonephritis and enhanced kidney function (blood urea nitrogen, 45\u00b74\u00a0\u00b1\u00a07\u00b75 versus 35\u00b76\u00a0\u00b1\u00a05\u00b71; albuminuria, 50\u00b71\u00a0\u00b1\u00a07\u00b71 versus 15\u00b77\u00a0\u00b1\u00a07\u00b71; glomerulonephritis, 2\u00b762\u00a0+\u00a00\u00b725 versus 2\u00a0+\u00a00\u00b73, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). In line with reduced IgG deposits in mice with <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> given curcumin, C9 deposits were reduced indicating reduced complement activation. Mice treated with curcumin had a significant reduction in the number of splenic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> B cells and the ratio of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19\u00a0:\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3 cells (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) with no change in the T\u2010cell population. Myeloperoxidase assay showed reduced macrophages in the kidney. However, a significant reduction in the M2 subset of splenic macrophages by apoferritin was prevented by curcumin, suggesting a protective function. Curcumin treatment reduced m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression of inflammatory proteins monocyte chemoattractant protein\u20101 and transforming growth factor\u2010\u03b2 and matrix proteins, fibronectin, laminin and collagen. Our results clearly illustrate that curcumin reduces glomerulosclerosis, improves kidney function and could serve as a therapeutic agent during serum sickness.<\/jats:p>","DOI":"10.1111\/imm.12079","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T14:25:10Z","timestamp":1359037510000},"page":"328-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Curcumin alleviates immune\u2010complex\u2010mediated glomerulonephritis in factor\u2010H\u2010deficient mice"],"prefix":"10.1111","volume":"139","author":[{"given":"Alexander","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Medicine The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Chaves","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Eadon","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Quigg","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessy J.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.06.040188.001113"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.545"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4813"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01893019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.07.287"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070664"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng912"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101299200"},{"key":"e_1_2_7_11_1","first-page":"344","article-title":"Interstrain variations in nephritogenicity of heterologous protein in mice","volume":"46","author":"Iskandar SS","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_7_12_1","first-page":"772","article-title":"Immune complex acute necrotizing glomerulonephritis with progression to diffuse glomerulosclerosis. 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