{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:37:27Z","timestamp":1792255047843,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Summary<\/jats:title>Impaired local cellular immunity contributes to the pathogenesis of persistent high\u2010risk human papillomavirus (HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>) infection and related cervical intraepithelial neoplasia (CIN<\/jats:styled-content>), but the underlying molecular mechanisms remain unclear. Recently, the programmed death 1\/programmed death 1 ligand (PD<\/jats:styled-content>\u20101\/PD<\/jats:styled-content>\u2010L<\/jats:styled-content>1; CD<\/jats:styled-content>279\/CD<\/jats:styled-content>274) pathway was demonstrated to play a critical role in attenuating T<\/jats:styled-content>\u2010cell responses and promoting T<\/jats:styled-content>\u2010cell tolerance during chronic viral infections. In this study, we examined the expression of PD<\/jats:styled-content>\u20101 and PD<\/jats:styled-content>\u2010L<\/jats:styled-content>1 on cervical T<\/jats:styled-content> cells and dendritic cells (DC<\/jats:styled-content>s), respectively, from 40 women who were HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>\u2010negative (\u2212) or HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>\u2010positive (+) with CIN<\/jats:styled-content> grades 0, I<\/jats:styled-content> and II<\/jats:styled-content>\u2013III<\/jats:styled-content>. We also measured interferon\u2010\u03b3, interleukin\u201012 (IL<\/jats:styled-content>\u201012) and IL<\/jats:styled-content>\u201010 in cervical exudates. The most common HPV<\/jats:styled-content> type was HPV<\/jats:styled-content> 16, followed by HPV<\/jats:styled-content> 18, 33, 51 and 58. PD<\/jats:styled-content>\u20101 and PD<\/jats:styled-content>\u2010L<\/jats:styled-content>1 expression on cervical T<\/jats:styled-content> cells and DC<\/jats:styled-content>s, respectively, was associated with HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> positivity and increased in parallel with increasing CIN<\/jats:styled-content> grade. The opposite pattern was observed for CD<\/jats:styled-content>80 and CD<\/jats:styled-content>86 expression on DC<\/jats:styled-content>s, which decreased in HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>(+) patients in parallel with increasing CIN<\/jats:styled-content> grade. Similarly, reduced levels of the T<\/jats:styled-content> helper type 1 cytokines interferon\u2010\u03b3 and IL<\/jats:styled-content>\u201012 and increased levels of the T<\/jats:styled-content> helper type 2 cytokine IL<\/jats:styled-content>\u201010 in cervical exudates correlated with HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> positivity and CIN<\/jats:styled-content> grade. Our results suggest that up\u2010regulation of the inhibitory PD<\/jats:styled-content>\u20101\/PD<\/jats:styled-content>\u2010L1 pathway may negatively regulate cervical cell\u2010mediated immunity to HPV<\/jats:styled-content> and contribute to the progression of HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>\u2010related CIN<\/jats:styled-content>. These results may aid in the development of PD<\/jats:styled-content>\u20101\/PD<\/jats:styled-content>\u2010L<\/jats:styled-content>1 pathway\u2010based strategies for immunotherapy of HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>\u2010related CIN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/imm.12101","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T21:17:46Z","timestamp":1364073466000},"page":"513-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":176,"title":["Increased expression of programmed death (PD)\u20101 and its ligand PD<\/scp>\u2010L1 correlates with impaired cell\u2010mediated immunity in high\u2010risk human papillomavirus\u2010related cervical intraepithelial neoplasia"],"prefix":"10.1111","volume":"139","author":[{"given":"Wen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics Chinese PLA (People's 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