{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:38:46Z","timestamp":1778834326735,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nuclear factor\u2010\u03baB\u2010inducing kinase (<jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content>) is known to play a critical role in maintaining proper immune function. This is exemplified in the spontaneous mutant mouse lacking functional <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content>, alymphoplasia (<jats:italic>aly<\/jats:italic>), which is simultaneously immune\u2010compromised and autoimmune\u2010prone. To investigate the role of <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content> in \u03b1\u03b2 T\u2010cell repertoire formation, we analysed T\u2010cell development in <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice bearing a transgenic <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>). Although there were no apparent abnormalities in the mature \u03b1\u03b2 T cells of non\u2010transgenic <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice, the maturation efficiency of idiotype<jats:sup>high+<\/jats:sup> T cells in the <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u2010transgenic mice was lower in <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice compared with those found in <jats:italic>aly<\/jats:italic>\/+ mice, suggesting that the mature \u03b1\u03b2 T\u2010cell repertoire could be altered by the absence of functional <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content>. In one strain of <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u2010transgenic <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice with a negatively selecting H\u20102 background, the proportion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>low+<\/jats:sup> idiotype<jats:sup>high+<\/jats:sup> cells, which are thought to potentially represent the \u03b3\u03b4 lineage of T cells, was markedly decreased. When the \u03b3\u03b4 T cells in non\u2010transgenic <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice were investigated, the proportion of \u03b3\u03b4 T cells in the peripheral organs of <jats:italic>aly<\/jats:italic>\/<jats:italic>aly<\/jats:italic> mice was found to be one\u2010half to one\u2010fifth of those in <jats:italic>aly<\/jats:italic>\/+ mice. Analyses of bone marrow chimera mice indicated that <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content> in host cells, rather than in donor cells was important for generating a normal number of peripheral \u03b3\u03b4 T cells. Collectively, these results suggest that <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content> could be involved in thymic positive selection of some \u03b1\u03b2 T cells and that <jats:styled-content style=\"fixed-case\">NIK<\/jats:styled-content> in non\u2010haematopoietic cells is important for the optimal development and\/or maintenance of \u03b3\u03b4 T cells.<\/jats:p>","DOI":"10.1111\/imm.12186","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:17:50Z","timestamp":1381544270000},"page":"222-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Significant involvement of nuclear factor\u2010\u03baB\u2010inducing kinase in proper differentiation of \u03b1\u03b2 and \u03b3\u03b4 T cells"],"prefix":"10.1111","volume":"141","author":[{"given":"Koji","family":"Eshima","sequence":"first","affiliation":[{"name":"Department of Immunology Kitasato University 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