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This mosquito\u2010borne disease has a great impact in tropical and subtropical areas of the world in terms of illness, mortality and economic costs, mainly due to the lack of approved vaccine or antiviral drugs. Infections with one of the four serotypes of <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20101\u20134) result in symptoms ranging from an acute, self\u2010limiting febrile illness, dengue fever, to severe dengue haemorrhagic fever or dengue shock syndrome. We reviewed the existing mouse models of infection, including the <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102\u2010adapted strain P23085. The role of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> chemokines, interleukin\u201017 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and invariant natural killer <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells in mediating the exacerbation of disease in immune\u2010competent mice is highlighted. Investigations in both immune\u2010deficient and immune\u2010competent mouse models of <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> infection may help to identify key host\u2013pathogen factors and devise novel therapies to restrain the systemic and local inflammatory responses associated with severe DENV infection.<\/jats:p>","DOI":"10.1111\/imm.12188","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T13:11:09Z","timestamp":1384953069000},"page":"143-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Dengue virus infection: current concepts in immune mechanisms and lessons from murine models"],"prefix":"10.1111","volume":"141","author":[{"given":"Rodrigo","family":"Guabiraba","sequence":"first","affiliation":[{"name":"Institute of Infection Immunity and Inflammation Glasgow Biomedical Research Centre College of Medical Veterinary and Life Sciences 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