{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:52:37Z","timestamp":1792705957892,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Summary<\/jats:title>The histamine 4 receptor (H<\/jats:styled-content>4R<\/jats:styled-content>) is expressed primarily on cells involved in inflammation and immune responses. Despite much research into inflammatory diseases, no drugs with favourable safety profiles are yet available for their treatment. The aim of the present study was to determine the potential anti\u2010inflammatory effect of 4\u2010methylhistamine (4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>) orJNJ<\/jats:styled-content>77777120 (JNJ<\/jats:styled-content>) and to explore the role ofH<\/jats:styled-content>4R<\/jats:styled-content>in a mouse model of carrageenan (C<\/jats:styled-content>g) \u2010induced pleurisy. A single dose of 4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>orJNJ<\/jats:styled-content>(30\u00a0mg\/kg) was administered intraperitoneally 1\u00a0hr beforeC<\/jats:styled-content>g administration. The results illustrate that both the numbers ofCD<\/jats:styled-content>4+<\/jats:sup>,CD<\/jats:styled-content>25+<\/jats:sup>,CD<\/jats:styled-content>4+<\/jats:sup>\u00a0CD<\/jats:styled-content>25+<\/jats:sup>,GITR<\/jats:styled-content>+<\/jats:sup>,GITR<\/jats:styled-content>+<\/jats:sup>\u00a0IL<\/jats:styled-content>\u201017A<\/jats:styled-content>+<\/jats:sup>\u2010expressingT<\/jats:styled-content>cells and the levels of T helper type 1 (T<\/jats:styled-content>h1)\/T<\/jats:styled-content>h17 cytokines were markedly increased in both theC<\/jats:styled-content>g\u2010treated and 4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>\u2010treated groups, whereas the cytokines produced byT<\/jats:styled-content>h2 cells were significantly decreased in the same groups. However,JNJ<\/jats:styled-content>treatment significantly decreased both the number ofT<\/jats:styled-content>\u2010cell subsets andGITR<\/jats:styled-content>+<\/jats:sup>,GITR<\/jats:styled-content>+<\/jats:sup>\u00a0IL<\/jats:styled-content>\u201017A<\/jats:styled-content>+<\/jats:sup>\u2010expressingT<\/jats:styled-content>cells, and the production ofT<\/jats:styled-content>h1\/T<\/jats:styled-content>h17 cytokines. Further,JNJ<\/jats:styled-content>up\u2010regulated the expression of theT<\/jats:styled-content>h2 cytokines.RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>analysis revealed an increased expression of interleukin\u20101\u03b2<\/jats:italic>, tumour necrosis factor\u2010\u03b1<\/jats:italic>, monocyte chemoattractant protein\u20101 and intercellular adhesion molecule\u20101 in theC<\/jats:styled-content>g\u2010treated and 4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>\u2010treated groups, which was reduced by treatment withJNJ<\/jats:styled-content>in lung tissues. Moreover, histological examinations revealed anti\u2010inflammatory effects ofJNJ<\/jats:styled-content>, whereas 4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>worsenedC<\/jats:styled-content>g\u2010induced inflammation. In conclusion, the results of the present work clearly indicate thatJNJ<\/jats:styled-content>possesses important anti\u2010inflammatory properties that are increased in 4\u2010M<\/jats:styled-content>eH<\/jats:styled-content>\u2010treated mice, suggesting thatH<\/jats:styled-content>4R<\/jats:styled-content>are involved in pleurisy and thatJNJ<\/jats:styled-content>has an anti\u2010inflammatory effect in associated disease conditions.<\/jats:p>","DOI":"10.1111\/imm.12257","type":"journal-article","created":{"date-parts":[[2014,1,25]],"date-time":"2014-01-25T08:36:42Z","timestamp":1390639002000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Role of a histamine 4 receptor as an anti\u2010inflammatory target in carrageenan\u2010induced pleurisy in mice"],"prefix":"10.1111","volume":"142","author":[{"given":"Sheikh Fayaz","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairy M. A.","family":"Zoheir","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"},{"name":"Department of Cell Biology National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala E.","family":"Abdel\u2010Hamied","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Girls) Department of Pathology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Alrashidi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabry M.","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"},{"name":"Department of Pharmacology and Toxicology College of Pharmacy Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Bakheet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkader E.","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel R. 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