{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:31:35Z","timestamp":1778164295014,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31070803"],"award-info":[{"award-number":["31070803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The c\u2010Jun <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010terminal kinase (<jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>) signalling pathway appears to act as a critical intermediate in the regulation of lymphocyte activation and proliferation. The majority of studies on the importance of <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content> are focused on its role in T helper responses, with very few reports addressing the mechanisms of <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content> in governing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 T\u2010cell\u2010mediated immunity. By using a well\u2010defined mousepox model, we demonstrate that <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content> is involved in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated antiviral responses. Deficiency of either <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>1 or <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>2 impaired viral clearance, subsequently resulting in an increased susceptibility to ectromelia virus in resistant mice. The impairment of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 responses in <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\u2010deficient mice was not directly due to an inhibition of effector T\u2010cell expansion, as both <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>2 had limited effect on the activation\u2010induced cell death of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells, and only <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>2\u2010deficient mice exhibited a significant change in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T\u2010cell proliferation after acute ectromelia virus infection. However, optimal activation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells and their effector functions require signals from both <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>2. Our results suggest that the <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content> pathway acts as a critical intermediate in antiviral immunity through regulation of the activation and effector function of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells rather than by altering their expansion.<\/jats:p>","DOI":"10.1111\/imm.12270","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T17:05:02Z","timestamp":1392915902000},"page":"603-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Defective antiviral <scp>CD<\/scp>8 T\u2010cell response and viral clearance in the absence of c\u2010Jun <scp>N<\/scp>\u2010terminal kinases"],"prefix":"10.1111","volume":"142","author":[{"given":"Yong\u2010Qin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology School of Medicine Nankai 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