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The Src homology domain protein B (Shb) adaptor protein was recently implicated as a regulator of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h cell differentiation. Shb is an integral component of the T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) signalling complex and in the absence of <jats:italic>Shb<\/jats:italic> the <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> is less responsive to stimulation, resulting in the preferential development of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 responses under conditions of <jats:italic>in vitro<\/jats:italic> stimulation. In the present study, we extend those observations to an <jats:italic>in vivo<\/jats:italic> situation using a murine model of atopic dermatitis. <jats:italic>Shb<\/jats:italic> knockout mice develop more pronounced symptoms of atopic dermatitis with increased localized oedema, epidermal hyperplasia and IgE production. Dermal infiltration of mast cells, eosinophils, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h cells and F4\/80<jats:sup>+<\/jats:sup> macrophages was also significantly increased in <jats:italic>Shb<\/jats:italic>\u2010deficient mice. This correlated with elevated transcription of the hallmark <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 cytokines interleukin\u20104 and interleukin\u20105. The loss of <jats:italic>Shb<\/jats:italic> therefore alters <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> signalling ability, thereby favouring the development of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2\u2010driven inflammation and exacerbating symptoms of allergy.<\/jats:p>","DOI":"10.1111\/imm.12286","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T08:43:06Z","timestamp":1395304986000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Absence of the adaptor protein Shb potentiates the <scp>T<\/scp> helper type 2 response in a mouse model of atopic dermatitis"],"prefix":"10.1111","volume":"143","author":[{"given":"Karin","family":"Gustafsson","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology Uppsala University Uppsala 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