{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:09:07Z","timestamp":1767164947459,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>\n \n Viral and host factors can influence\n HIV<\/jats:styled-content>\n \u20101 progression, among them human leucocyte antigen (\n HLA<\/jats:styled-content>\n ) has shown the strongest effect. However, studies on the functional contribution of\n HLA<\/jats:styled-content>\n in controlling\n HIV<\/jats:styled-content>\n progression toward\n AIDS<\/jats:styled-content>\n are limited by multiple issues, including the viral strain variability within the study subjects. In this study, in a cohort of children infected with a monophyletic strain (\n CRF<\/jats:styled-content>\n 02_\n AG<\/jats:styled-content>\n ) during an outbreak, we evaluated the\n HIV<\/jats:styled-content>\n \u20101\n G<\/jats:styled-content>\n ag,\n V<\/jats:styled-content>\n if,\n V<\/jats:styled-content>\n pr,\n T<\/jats:styled-content>\n at and hepatitis\n C<\/jats:styled-content>\n virus\n E<\/jats:styled-content>\n 1\/\n E<\/jats:styled-content>\n 2 (as control) proteins circulating in a cohort for the capability to be presented by the\n HLA<\/jats:styled-content>\n molecules in the same population. A total of 70 Non\u2010progressors and 37 Progressors to\n AIDS<\/jats:styled-content>\n were evaluated. In the presence of a constant capability of\n HIV<\/jats:styled-content>\n \u20101 to mutate in the region containing epitopes of\n G<\/jats:styled-content>\n ag protein, the number of epitopes recognized\n in silico<\/jats:italic>\n by the combination of the\n HLA<\/jats:styled-content>\n alleles along the Gag consensus sequence is significantly higher in the Non\u2010progressors compared with Progressors (\n HLA<\/jats:styled-content>\n \u2010A: Non\u2010progressors\u00a0=\u00a01\u00b7532\u00a0\u00b1\u00a01\u00b7211, Progressors\u00a0=\u00a00\u00b77714\u00b1 1\u00b7031,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b70016;\n HLA<\/jats:styled-content>\n \u2010B: Non\u2010progressors\u00a0=\u00a01\u00b7556\u00a0\u00b1\u00a01\u00b7298, Progressors\u00a0=\u00a01\u00b7000 \u00b1\u00a00\u00b7817,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b70319;\n HLA<\/jats:styled-content>\n \u2010\n DR<\/jats:styled-content>\n : Non\u2010progressors\u00a0=\u00a013\u00b730\u00b1 9\u00b7488, Progressors\u00a0=\u00a07\u00b7294\u00a0\u00b1\u00a06\u00b7952,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b70006). Similar results were obtained for the other\n HIV<\/jats:styled-content>\n \u20101 proteins\n V<\/jats:styled-content>\n if and\n V<\/jats:styled-content>\n pr, whereas no differences were obtained in the number of epitopes for the hepatitis\n C<\/jats:styled-content>\n virus\n E<\/jats:styled-content>\n 1\/\n E<\/jats:styled-content>\n 2 protein sequence or for the scrambled\n HIV<\/jats:styled-content>\n \u20101 sequence. Finally, the results were confirmed also in a subgroup of subjects where both\n HLA<\/jats:styled-content>\n typing and\n G<\/jats:styled-content>\n ag sequence were available. In conclusion, in the absence of bias due to viral strain diversity, it is the overall fitting of the\n HLA<\/jats:styled-content>\n molecules that are capable of better binding\n HIV<\/jats:styled-content>\n \u20101 proteins in determining the major role in the control of\n HIV<\/jats:styled-content>\n \u20101 replication and progression to\n AIDS<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/imm.12344","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T11:28:08Z","timestamp":1403350088000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of individual's\n T<\/scp>\n \u2010cell immunome in controlling\n HIV<\/scp>\n \u20101 progression"],"prefix":"10.1111","volume":"143","author":[{"given":"Alba","family":"Grifoni","sequence":"first","affiliation":[{"name":"Department of Biology University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Montesano","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Palma","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases \u2018Bambino Ges\u00f9\u2019 Children's Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Giovannetti","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Castelli\u2010Gattinara","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases \u2018Bambino Ges\u00f9\u2019 Children's Hospital Rome 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Methodologies University of Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Colizzi","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Amicosante","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, and Prevention University of Rome \u2018Tor Vergata\u2019 Rome Italy"},{"name":"ProxAgen Ltd Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01337.x"},{"key":"e_1_2_7_3_1","first-page":"I\u201343","volume-title":"HIV Molecular Immunology 2001","author":"Trachtenberg 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