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Although the ability of pro\u2010inflammation in periodontitis has been widely investigated, the other biological functions of IL\u201017, including its role in bone remodelling and the underlying molecular mechanisms, have not been well clarified. In the present study, IL\u201017 could significantly enhance the expression of receptor activator for nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B ligand (RANKL) and inhibit the expression of osteoprotegerin (OPG) in human periodontal ligament cells, the two critical indicators for osteoclastogenesis, suggesting that IL\u201017 may play a destructive role in the pathogenesis of periodontal bone remodelling. Pharmaceutical signal inhibitors targeted at mitogen\u2010activated protein kinases, Akt or nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B signals, inhibited IL\u201017\u2010induced RANKL and OPG regulation. Notably, the enhancement of RANKL was significantly blocked by the inhibitors of c\u2010Jun N\u2010terminal kinase and nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B signals. The upstream signals were further investigated with the small interfering RNA. Both tumour necrosis factor receptor\u2010associated factor 6 and TNF receptor associated factor (TRAF) family member\u2010associated nuclear factor <jats:italic>\u03ba<\/jats:italic>\u2010light\u2010chain enhancer of activated B cells (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) activator (TANK)\u2010 binding kinase 1 were found to be the critical signal molecules for IL\u201017\u2010dependent RANKL regulation in human periodontal ligament cells. These findings may provide comprehensive understanding of the role of IL\u201017 in the pathogenesis of periodontitis and might also provide a reasonable route for periodontitis therapy.<\/jats:p>","DOI":"10.1111\/imm.12395","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T09:51:40Z","timestamp":1411984300000},"page":"472-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Interleukin\u201017 regulates the expressions of <scp>RANKL<\/scp> and <scp>OPG<\/scp> in human periodontal ligament cells via <scp>TRAF<\/scp>6\/<scp>TBK<\/scp>1\u2010<scp>JNK<\/scp>\/<scp>NF<\/scp>\u2010<i>\u03ba<\/i>B pathways"],"prefix":"10.1111","volume":"144","author":[{"given":"Danping","family":"Lin","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Jiangsu 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