{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:09:36Z","timestamp":1790374176139,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","award":["UBACyT 2011-2014"],"award-info":[{"award-number":["UBACyT 2011-2014"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","award":["CONICET PIP 2011-2013"],"award-info":[{"award-number":["CONICET PIP 2011-2013"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The modulatory effects of solar\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    radiation on the immune system have been widely studied. As the skin is the main target of\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    radiation, our purpose was to compare the impact on skin innate immunity of two contrasting ways to be exposed to sunlight. Hairless mice were\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    irradiated with a single high\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    dose simulating a harmful exposure, or with repetitive low\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    doses simulating short occasional daily exposures. Skin samples were taken at different times after\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    irradiation to evaluate skin histology, inflammatory cell recruitment, epidermal T\u2010cell population and the mitochondrial function of epidermal cells. The transcriptional profiles of pro\u2010inflammatory cytokines, chemokines, antimicrobial peptides and Toll\u2010like receptors were evaluated by\n                    <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    in tissue homogenates. Finally, a lymphangiography was performed to assess modification in the lymphatic vessel system. A single high\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    dose produces a deep inflammatory state characterized by the production of pro\u2010inflammatory cytokines and chemokines that, in turn, induces the recruitment of neutrophils and macrophages into the irradiated area. On the other hand, repetitive low\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    doses drive the skin to a photo\u2010induced alert state in which there is no sign of inflammation, but the epithelium undergoes changes in thickness, the lymphatic circulation increases, and the transcription of antimicrobial peptides is induced.\n                  <\/jats:p>","DOI":"10.1111\/imm.12427","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T16:00:52Z","timestamp":1417190452000},"page":"82-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Time\u2013course study of different innate immune mediators produced by UV\u2010irradiated skin: comparative effects of short and daily versus a single harmful UV exposure"],"prefix":"10.1111","volume":"145","author":[{"given":"Eliana M.","family":"Cela","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda (Universidad de Buenos Aires)\u00a0\u2013\u00a0Instituto de Estudios de la Inmunidad Humoral (IDEHU\u2013CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Friedrich","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda (Universidad de Buenos Aires)\u00a0\u2013\u00a0Instituto de Estudios de la Inmunidad Humoral (IDEHU\u2013CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela L.","family":"Paz","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda (Universidad de Buenos Aires)\u00a0\u2013\u00a0Instituto de Estudios de la Inmunidad Humoral (IDEHU\u2013CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia I.","family":"Vanzulli","sequence":"additional","affiliation":[{"name":"Instituto de Estudios Oncol\u00f3gicos Academia Nacional de Medicina Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Leoni","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda (Universidad de Buenos Aires)\u00a0\u2013\u00a0Instituto de Estudios de la Inmunidad Humoral (IDEHU\u2013CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Gonz\u00e1lez Maglio","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda (Universidad de Buenos Aires)\u00a0\u2013\u00a0Instituto de Estudios de la Inmunidad Humoral (IDEHU\u2013CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3175"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00786.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(02)00028-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.7811"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01313.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.11.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01082.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1310"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12536743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90111-8"},{"key":"e_1_2_8_12_1","first-page":"146","article-title":"The skin as an immune organ","volume":"160","author":"Salmon JK","year":"1994","journal-title":"West J Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2622"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874944"},{"key":"e_1_2_8_15_1","unstructured":"Sun protection.A Primary Teaching Resource. 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