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Non\u2010obese diabetic (<jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>) mice spontaneously develop lacrimal and salivary gland autoimmunity and are a well\u2010characterized model of Sj\u00f6gren syndrome. Lacrimal gland disease in <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mice is male\u2010specific, but the role of Treg cells in this sex\u2010specificity is not known. This study aimed to determine if male\u2010specific autoimmune dacryoadenitis in the <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mouse model of Sj\u00f6gren syndrome is the result of lacrimal gland\u2010protective Treg cell dysfunction. An adoptive transfer model of Sj\u00f6gren syndrome was developed by transferring cells from the lacrimal gland\u2010draining cervical lymph nodes of <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mice to lymphocyte\u2010deficient <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice. Transfer of bulk cervical lymph node cells modelled the male\u2010specific dacryoadenitis that spontaneously develops in <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mice. Female to female transfers resulted in dacryoadenitis if the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> Treg\u2010enriched population was depleted before transfer; however, male to male transfers resulted in comparable dacryoadenitis regardless of the presence or absence of Treg cells within the donor cell population. Hormone manipulation studies suggested that this Treg cell dysfunction was mediated at least in part by androgens. Surprisingly, male Treg cells were capable of preventing the transfer of dacryoadenitis to female recipients. These data suggest that male\u2010specific factors promote reversible dysfunction of lacrimal gland\u2010protective Treg cells and, to our knowledge, form the first evidence for reversible organ\u2010protective Treg cell dysfunction in organ\u2010specific autoimmunity.<\/jats:p>","DOI":"10.1111\/imm.12439","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T07:53:40Z","timestamp":1420703620000},"page":"232-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reversible lacrimal gland\u2010protective regulatory T\u2010cell dysfunction underlies male\u2010specific autoimmune dacryoadenitis in the non\u2010obese diabetic mouse model of Sj\u00f6gren syndrome"],"prefix":"10.1111","volume":"145","author":[{"given":"Scott M.","family":"Lieberman","sequence":"first","affiliation":[{"name":"Stead Family Department of Pediatrics Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Portia A.","family":"Kreiger","sequence":"additional","affiliation":[{"name":"Department of Pathology Nemours\/A.I. 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